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Retinal Protection of New Nutraceutical Formulation.
Pharmaceutics
January 2025
Innovation and Medical Science, SIFI S.p.A., 95025 Aci Sant'Antonio, Italy.
Retinal ganglion cell (RGC) protection represents an unmet need in glaucoma. This study assessed the neuroprotective, antioxidant, and anti-inflammatory effect of a new nutraceutical formulation named Epicolin, based on citicoline, homotaurine, epigallocatechin-3-gallate, forskolin, and vitamins, through in vitro and in vivo studies. The neuroprotective effect of Epicolin or its single components, and Epicolin compared to an untreated control and two marketed formulations [Formulation G (FG) and N (FN)], was evaluated in neuroblastoma cells (SH-SY5Y) challenged with staurosporine.
View Article and Find Full Text PDFSelective Laser Sintering 3D Printing of Carvedilol Tablets: Enhancing Dissolution Through Amorphization.
Pharmaceutics
December 2024
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Background/objectives: Selective laser sintering (SLS) is one of the most promising 3D printing techniques for pharmaceutical applications as it offers numerous advantages, such as suitability to work with already approved pharmaceutical excipients, the elimination of solvents, and the ability to produce fast-dissolving, porous dosage forms with high drug loading. When the powder mixture is exposed to elevated temperatures during SLS printing, the active ingredients can be converted from the crystalline to the amorphous state, which can be used as a strategy to improve the dissolution rate and bioavailability of poorly soluble drugs. This study investigates the potential application of SLS 3D printing for the fabrication of tablets containing the poorly soluble drug carvedilol with the aim of improving the dissolution rate of the drug by forming an amorphous form through the printing process.
View Article and Find Full Text PDFDirect Ink Writing 3D Printing Polytetrafluoroethylene/Polydimethylsiloxane Membrane with Anisotropic Surface Wettability and Its Application in Oil-Water Separation.
Polymers (Basel)
January 2025
State Key Laboratory of Material Processing and Die & Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Biological surfaces with physical discontinuity or chemical heterogeneity possess special wettability in the form of anisotropic wetting behavior. However, there are several challenges in designing and manufacturing samples with anisotropic wettability. This study investigates the fabrication of PTFE/PDMS grid membranes using Direct Ink Writing (DIW) 3D printing for oil-water separation applications.
View Article and Find Full Text PDFInfections: Bridging Clinical Observations and Epidemiological Insights.
J Clin Med
January 2025
Department of Medical Specialties I, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Purpose: is the main etiologic agent implicated in primary amoebic meningoencephalitis (PAM). It is also known as the brain-eating amoeba because of the severe brain inflammation following infection, with a survival rate of about 5%. This review aims to identify infections and evaluate patients' progression.
View Article and Find Full Text PDFTuning Electrical Conductivity and Ultrafast Optical Nonlinearity of Reduced-GO Films Ablated by Femtosecond Laser Direct Writing.
Molecules
January 2025
Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University, Hefei 230601, China.
Carbon-based nanomaterials with excellent electrical and optical properties are highly sought after for a plethora of hybrid applications, ranging from advanced sustainable energy storage devices to opto-electronic components. In this contribution, we examine in detail the dependence of electrical conductivity and the ultrafast optical nonlinearity of graphene oxide (GO) films on their degrees of reduction, as well as the link between the two properties. The GO films were first synthesized through the vacuum filtration method and then reduced partially and controllably by way of femtosecond laser direct writing with varying power doses.
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