AI Article Synopsis
- The objective of the study was to analyze the connection between sarcopenia (muscle loss) and negative outcomes like mortality, cancer recurrence, and complications after radical cystectomy in bladder cancer patients.* -
- The research included 21 observational studies with nearly 5,000 patients and found that those with sarcopenia faced significantly higher risks of overall and cancer-specific mortality, as well as lower chances of remaining cancer-free post-surgery.* -
- The study concluded that sarcopenia in bladder cancer patients undergoing radical cystectomy is linked to worse survival outcomes and a greater likelihood of experiencing postoperative complications.*
Article Abstract
Objective: To provide synthesized evidence on the association between sarcopenia and risk of mortality, recurrence and postoperative complications in patients with bladder cancer and undergoing radical cystectomy (RC).
Methods: Only studies with observational design that investigated the association between sarcopenia and outcomes of interest among patients with bladder cancer undergoing RC were included. The outcomes of interest were mortality, recurrence, and postoperative complications. The systematic search was conducted using three large databases, that is, PubMed, EMBASE, and Scopus. A random effects model was used for the analysis and pooled effect sizes were reported as odds ratio (OR) or hazards ratio (HR) along with 95% confidence intervals (CIs).
Results: A total of 21 studies with 4997 patients were included. Compared to non-sarcopenic subjects, those with sarcopenia had increased risk of all-cause mortality (HR 1.45, 95% CI: 1.32, 1.61), cancer-specific mortality (HR 1.74, 95% CI: 1.49, 2.03) and a lower recurrence free survival (HR 1.84, 95% CI: 1.30, 2.62). Patients with sarcopenia also had higher risk of developing complications within 90 days postoperatively (OR 1.77, 95% CI: 1.23, 2.55).
Conclusion: Sarcopenia among patients with bladder cancer and managed using RC is associated with adverse survival outcomes and an increased risk of postoperative complications.
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| http://dx.doi.org/10.1177/00369330241234690 | DOI Listing |
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