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A Comprehensive Review of the Latest Trends in Spray Freeze Drying and Comparative Insights with Conventional Technologies.
Pharmaceutics
November 2024
Laboratory of Process Analysis and Design, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechneiou St. Zografou Campus, 15780 Athens, Greece.
Spray freeze drying (SFD) represents an emerging drying technique designed to produce a wide range of pharmaceuticals, foods, and active components with high quality and enhanced stability due to their unique structural characteristics. This method combines the advantages of the well-established techniques of freeze drying (FD) and spray drying (SD) while overcoming their challenges related to high process temperatures and durations. This is why SFD has experienced steady growth in recent years regarding not only the research interest, which is reflected by the increasing number of literature articles, but most importantly, the expanded market adoption, particularly in the pharmaceutical sector.
View Article and Find Full Text PDFArtificial light at night alters risk-related behaviors of the ground-dwelling isopod Porcellionids pruinosus.
J Exp Biol
January 2025
Department of Life Sciences, University of Trieste, Trieste, Italy.
Artificial light at night (ALAN) has emerged as a significant ecological disruptor, affecting various behavioral and physiological processes in numerous species. This study investigated the impact of ALAN on the risk-related behaviors and activity patterns of the ground-dwelling isopod, Porcellionides pruinosus. Isopods were exposed to three different illuminance conditions (<0.
View Article and Find Full Text PDFExploring the patient's recovery journey and information needs following a shoulder fracture: A qualitative interview study.
PLoS One
December 2024
Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, United Kingdom.
Background: Shoulder fractures (proximal humerus fractures) are common, painful, debilitating injuries. Recovery is a long process often hindered by complications such as mal-union and frozen shoulder. The purpose of this qualitative study was to explore the experiences and information needs of people at different time points after a shoulder fracture and how views on recovery change over time.
View Article and Find Full Text PDFNGS Detects Extensive Genomic Alterations in Survivors of Irradiated Normal Human Fibroblast Cells.
Radiat Res
January 2025
Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany.
It is thought that cells surviving ionizing radiation exposure repair DNA double-strand breaks (DSBs) and restore their genomes. However, the recent biochemical and genetic characterization of DSB repair pathways reveals that only homologous recombination (HR) can function in an error-free manner and that the non-homologous end joining (NHEJ) pathways canonical NHEJ (c-NHEJ), alternative end joining (alt-EJ), and single-strand annealing (SSA) are error-prone, and potentially leave behind genomic scars and altered genomes. The strong cell cycle restriction of HR to S/G2 phases and the unparalleled efficiency of c-NHEJ throughout the cell cycle, raise the intriguing question as to how far a surviving cell "reaches" after repairing the genome back to its pre-irradiation state.
View Article and Find Full Text PDFObserved Effects on Very Early Pregnancy Linked to Ambient PM Exposure in China among Women Undergoing Fertilization-Embryo Transfer.
Environ Health (Wash)
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
The adverse effect of ambient PM exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM exposure on the VEP using the fertilization and embryo transfer platform and high-resolution PM data in China. We first investigated the association between PM exposure 1 week before and 1 week after the embryo transfer date and VEP.
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