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| http://dx.doi.org/10.1186/s12864-024-10105-8 | DOI Listing |
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Abnormal Astrocyte Heterogeneity in the Dentate Gyrus of Rats Prone to Audiogenic Seizures Can Be Corrected by the Nootropic Drug Piracetam.
Hippocampus
January 2025
Sechenov Institute of Evolutionary Physiology and Biochemistry, The Russian Academy of Sciences, Saint Petersburg, Russia.
Accumulating evidence indicates that inherited astrocyte dysfunction can be a primary trigger for epilepsy development; however, the available data are rather limited. In addition, astrocytes are considered as a perspective target for the design of novel and improvement of the existing antiepileptic therapy. Piracetam and related nootropic drugs are widely used in the therapy of various epileptic disorders, but detailed mechanisms of racetams action and, in particular, their effects on glial functions are poorly understood.
View Article and Find Full Text PDFMacrophages excite muscle spindles with glutamate to bolster locomotion.
Nature
December 2024
Faculty of Medicine, Department of Brain Sciences, Imperial College London, London, UK.
Article Synopsis
- The stretch reflex is a key part of movement, involving muscle spindles that detect tension changes and trigger muscle contractions via nerve signals in the spinal cord.
- Researchers have discovered a unique type of macrophage in muscle spindles that can produce and release glutamate, enhancing communication between sensory neurons and muscles.
- Silencing these macrophages disrupts the stretch reflex and affects locomotion in mice, suggesting that they play a crucial role in sensory feedback and movement regulation, with potential implications for new treatments in movement disorders.
Brain and behavioural anomalies caused by haploinsufficiency are corrected by vitamin B12.
Life Sci Alliance
February 2025
Institute of Genetics and Biophysicshttps://ror.org/04zaypm56 of the National Research Council, Naples, Italy
The brain-related phenotypes observed in 22q11.2 deletion syndrome (DS) patients are highly variable, and their origin is poorly understood. Changes in brain metabolism might contribute to these phenotypes, as many of the deleted genes are involved in metabolic processes, but this is unknown.
View Article and Find Full Text PDFAbnormal metabolites in the dorsolateral prefrontal cortex of female epilepsy patients with migraine without aura.
Neuroreport
December 2024
Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, China.
Epilepsy and migraine without aura (MWoA) are often comorbid, but the exact mechanisms are unclear. Magnetic resonance spectroscopy (1H-MRS) may help to understand the neurometabolic mechanisms in patients with epilepsy comorbid with MWoA (EWM). In this prospective cross-sectional study, we recruited 64 female patients, including 24 with EWM, 20 with epilepsy, and 20 with MWoA, as well as 20 age-level-matched and educational-level-matched female healthy controls from our hospital between August 2021 and November 2022.
View Article and Find Full Text PDFImpact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial.
Int J Biol Markers
December 2024
Uro-Gynecological Medical Oncology, Istituto Nazionale Tumori, IRCCS-Fondazione G. Pascale, Napoli, Italy.
Article Synopsis
- In ovarian cancer, a comprehensive study examined various metabolism-related markers to understand their prognostic value, but results showed mixed outcomes in large patient groups.
- The study used advanced techniques on tissue samples from over 300 patients to analyze markers tied to glycolysis, glutamine metabolism, and hypoxia, but found that only one marker (GLS) hinted at a connection to patient survival, which was not statistically significant after adjustments.
- Ultimately, the research highlights the diversity of metabolism markers in ovarian cancer and suggests their expression patterns may still be relevant for future drug development, even if they don't currently correlate with treatment outcomes.
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