Rearrangements in the Scholl reaction have traditionally been serendipitous, lacking a systematic approach for synthesizing rearranged and cyclized products. This paper introduces a strategic pathway to achieve rearranged-cyclized thienotetrahelicene derivatives over direct-cyclized chrysenothiophene derivatives by finely modifying the reaction conditions and tuning the electronic properties in Scholl-type reaction precursors, tetraarylthiophenes. Through careful design principles, we demonstrate the programmable synthesis of these distinct products.
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Rearrangements in the Scholl reaction have traditionally been serendipitous, lacking a systematic approach for synthesizing rearranged and cyclized products. This paper introduces a strategic pathway to achieve rearranged-cyclized thienotetrahelicene derivatives over direct-cyclized chrysenothiophene derivatives by finely modifying the reaction conditions and tuning the electronic properties in Scholl-type reaction precursors, tetraarylthiophenes. Through careful design principles, we demonstrate the programmable synthesis of these distinct products.
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