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A health security-based framework for prioritizing regions for digital learning in complex health emergencies.
Front Public Health
January 2025
ECHO Institute and Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Digital health and learning have expanded significantly in recent decades though their use in settings of acute health emergencies has only recently begun. Growing experience among organizations working in the digital health and learning space suggest that virtual communities of practice in these areas may have value in response to health emergencies. Evaluation of recent virtual programs applied in acute health emergencies suggest that a pre-established digital learning network can serve as a valuable resource when an acute health emergency strikes.
View Article and Find Full Text PDFConsensus representation of multiple cell-cell graphs from gene signaling pathways for cell type annotation.
BMC Biol
January 2025
Research Office, City University of Hong Kong (Dongguan), Dongguan, 523000, China.
Background: Recent advancements in single-cell RNA sequencing have greatly expanded our knowledge of the heterogeneous nature of tissues. However, robust and accurate cell type annotation continues to be a major challenge, hindered by issues such as marker specificity, batch effects, and a lack of comprehensive spatial and interaction data. Traditional annotation methods often fail to adequately address the complexity of cellular interactions and gene regulatory networks.
View Article and Find Full Text PDFMulti-SpinX: An advanced framework for automated tracking of mitotic spindles and kinetochores in multicellular environments.
Comput Biol Med
January 2025
Center for Cell Dynamics, School of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom; The Alan Turing Institute, London, NW1 2DB, United Kingdom. Electronic address:
SpinX, an AI-guided spindle tracking software, allows the 3-dimensional (3D) tracking of metaphase spindle movements in mammalian cells. Using over 900 images of dividing cells, we create the Multi-SpinX framework to significantly expand SpinX's applications: a) to track spindles and cell cortex in multicellular environments, b) to combine two object tracking (spindle with kinetochores marked by centromeric probes) and c) to extend spindle tracking beyond metaphase to prometaphase and anaphase stages where spindle morphology is different. We have used a human-in-the-loop approach to assess our optimisation steps, to manually identify challenges and to build a robust computational pipeline for segmenting kinetochore pairs and spindles.
View Article and Find Full Text PDFIncreasing Access Through Integration: Behavioral Health Services and Beyond.
Am J Public Health
January 2025
Della Hughes Carter, Mary Claire Meimers, and Emily Fowler Bemben are with the Kirkhof College of Nursing, Grand Rapids, MI.
An academic health center (AHC) that provides primary care to an urban, underresourced population recognized the need for an integrated model of care to address behavioral health needs. The Ambulatory Integration of the Medical and Social (AIMS) Collaborative Care Model's five pillars provided the framework and enhanced outcomes through tailored initiatives at the AHC, expanding to onsite satellite locations in senior subsidized housing, and through telehealth services. The results showed increased access to behavioral health care and improved depression and anxiety symptoms.
View Article and Find Full Text PDFRepeatome landscapes and cytogenetics of hortensias provide a framework to trace Hydrangea evolution and domestication.
Ann Bot
January 2025
Graduate School of Human Development and Environment, Kobe University, Nada-ku, Kobe, 657-8501, Japan.
Background And Aims: Ornamental hortensias are bred from a reservoir of over 200 species in the genus Hydrangea s.l. (Hydrangeaceae), and are valued in gardens, households and landscapes across the globe.
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