AI Article Synopsis
- The study aimed to explore the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and erosive esophagitis (EE), as the link was not well understood.
- It analyzed data from 1,578 patients over two years, finding that men had a higher rate of developing EE compared to women, with specific odds ratios indicating a correlation between MASLD and EE in men and older individuals.
- The results highlighted that risk factors for developing EE varied based on sex and age, particularly emphasizing that those aged 50 and older with multiple MASLD components are at an increased risk for developing EE.
Article Abstract
Background And Aim: Although erosive esophagitis (EE) is associated with fatty liver and metabolic dysregulation, the association between EE and metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. Thus, this study aimed to investigate the longitudinal association between MASLD and EE.
Methods: We included 1578 patients without EE at baseline who underwent more than two health checkups over 2 years. Generalized estimation equations were used to analyze associations between MASLD and EE according to repeated measures at baseline and most recent stages.
Results: EE development rates in men and women were 14.5% and 7.2%, respectively. After adjusting for lifestyle habits, the odds ratios of MASLD for EE development in men and women were 1.907 (95% confidence interval [CI]: 1.289-2.832, P < 0.005) and 1.483 (95% CI: 0.783-2.811, P = 0.227), respectively. In the subgroup analysis, after adjusting for lifestyle habits, among men and women aged ≥50 years with more than three MASLD components, the odds ratios for EE development were 2.408 (95% CI: 1.505-3.855, P < 0.001) and 2.148 (95% CI: 1.093-4.221, P < 0.05), respectively. After adjusting for various factors, the significant risk factors for EE development were different between men and women.
Conclusion: The influence of MASLD and other factors on EE development differed by sex and age. Particularly, patients aged ≥50 years with MASLD and with an increased number of MASLD components should be considered at increased risk for EE.
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| http://dx.doi.org/10.1111/jgh.16530 | DOI Listing |
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