Seven new terpenoids, including six sacculatane diterpenoids plagiochilarins A-F (-), and one -2,3--aromandrane sesquiterpenoid plagiochilarin H () with a 6/7/3/5 tetracyclic scaffold, alongside three known compounds, were obtained from the Chinese liverwort Inoue. Plagiochilarin B () was unpredictably converted to the more stable artifact under acid catalysis through cyclic ether formation. The reaction mechanism was reasonably deduced and experimentally verified. The structures of these terpenoids were determined by analysis of MS and NMR spectroscopic data and single-crystal X-ray diffraction. The inhibitory effect of all of the isolates was evaluated on the growth of two strains, wild strain SC5314 and efflux pump-deficient strain DSY654. However, only plagiochilarin H () showed a MIC value of 16 μg/mL against DSY654.
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Sacculatane Diterpenoids from the Liverwort Collected in China.
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