Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study.

Sci Rep

Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Published: February 2024

AI Article Synopsis

  • Current DCE MRI techniques require full doses of gadolinium-based contrast agents (GBCA), which can be a limitation.
  • This study tested a new protocol using a lower GBCA dose in patients with brain tumors to obtain high-resolution kinetic parameters through advanced imaging methods.
  • Results indicate that the new low-dose protocol not only offers accurate measurements comparable to full doses but also correlates well with important tissue characteristics like microvessel density.

Article Abstract

A key limitation of current dynamic contrast enhanced (DCE) MRI techniques is the requirement for full-dose gadolinium-based contrast agent (GBCA) administration. The purpose of this feasibility study was to develop and assess a new low GBCA dose protocol for deriving high-spatial resolution kinetic parameters from brain DCE-MRI. Nineteen patients with intracranial skull base tumours were prospectively imaged at 1.5 T using a single-injection, fixed-volume low GBCA dose, dual temporal resolution interleaved DCE-MRI acquisition. The accuracy of kinetic parameters (v K, v) derived using this new low GBCA dose technique was evaluated through both Monte-Carlo simulations (mean percent deviation, PD, of measured from true values) and an in vivo study incorporating comparison with a conventional full-dose GBCA protocol and correlation with histopathological data. The mean PD of data from the interleaved high-temporal-high-spatial resolution approach outperformed use of high-spatial, low temporal resolution datasets alone (p < 0.0001, t-test). Kinetic parameters derived using the low-dose interleaved protocol correlated significantly with parameters derived from a full-dose acquisition (p < 0.001) and demonstrated a significant association with tissue markers of microvessel density (p < 0.05). Our results suggest accurate high-spatial resolution kinetic parameter mapping is feasible with significantly reduced GBCA dose.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10902320PMC
http://dx.doi.org/10.1038/s41598-024-53871-xDOI Listing

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