AI Article Synopsis
- Epstein-Barr Virus (EBV) can lead to serious health issues, like post-transplant lymphoproliferative disorder (PTLD), particularly in children who have undergone organ transplants.
- Despite advancements in preventing EBV-related diseases, there are still many unanswered questions regarding their management and prevention.
- This manuscript aims to outline important recommendations from expert guidelines for managing EBV risks in pediatric patients undergoing solid organ and hematopoietic cell transplants, along with insights on measuring EBV viral loads.
Article Abstract
Epstein-Barr Virus (EBV) diseases, including EBV-associated post-transplant lymphoproliferative disorder (PTLD) remain important causes of morbidity and mortality in children undergoing solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT). Despite progress in the prevention of EBV disease including PTLD (EBV/PTLD) in HCT, key questions in the prevention, and management of these infectious complications remain unanswered. The goal of this manuscript is to highlight key points and recommendations derived from the consensus guidelines published by the International Pediatric Transplant Association and the European Conference on Infections in Leukemia for children undergoing SOT and HCT, respectively. Additionally, we provide background and guidance on the use of EBV viral load measurement in the prevention and management of these children.
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| http://dx.doi.org/10.1093/jpids/piad097 | DOI Listing |
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