Department of Neurosurgery, School of Medicine, Emory University, Atlanta, GA, USA.
Published: February 2024
AI Article Synopsis
Article Abstract
Introduction: Spheno-orbital meningiomas (SOMs) represent a distinct subtype of meningioma characterized by their unique multi-compartmental invasion pattern. Previous studies have investigated correlations between SOMs and visual manifestations. However, our comprehension of pain associated with SOMs remains limited. This study aims to provide insight into the pathophysiology underlying SOM-related pain through measurements of tumor volume and superior orbital fissure (SOF) narrowing.
Methods: This retrospective study included patients who underwent surgical resection of a SOM between 2000 and 2022. Preoperative CT and/or MRI scans were analyzed, and the tumor volume of each segment was measured. Bony 3D reconstructions were used to measure the area of the SOF, and SOF narrowing was calculated.
Results: The study cohort included 66 patients diagnosed with SOMs, among which 25.8% (n = 17) presented with pain. Postoperatively, 14/17 (82.4%) of patients reported pain improvement. There was no significant correlation between the total volume or the volume of tumor within each compartment and the presence of pain on presentation (p > 0.05). The median SOF narrowing was significantly different between patients presenting with and without tumor-associated pain with median of 11 mm (IQR 2.8-22.3) and 2 mm (IQR 0-6), respectively (p = 0.005). Using logistic regression, a significant correlation between the degree of SOF narrowing and the presence of SOM-associated pain on presentation was identified, with an aOR of 1.2 (95% CI 1.12-1.3, p = 0.02).
Conclusion: While the exact cause of tumor-associated pain remains unclear, SOF narrowing seems to play a role in pain among SOM patients. Based on the radiological characteristics, SOF neurovascular decompression is recommended in SOM patients.
This radiologic work aimed to display the alteration in the superior orbital fissure (SOF) morphology in the pediatric population with advancing age. This pediatric examination consisted of computed tomography images of 180 subjects (90 males/90 females) aged 1-18 years. The length (SOF-L) and width (SOF-W) of SOF were measured, and its shape was noted.
This study investigates whether reducing epistasis and pleiotropy enhances mutational robustness in evolutionary adaptation, utilizing an indirect encoded model within the "survival of the flattest" (SoF) fitness landscape. By simulating genetic variations and their phenotypic consequences, we explore organisms' adaptive mechanisms to maintain positions on higher, narrower evolutionary peaks amidst environmental and genetic pressures. Our results reveal that organisms can indeed sustain their advantageous positions by minimizing the complexity of genetic interactions-specifically, by reducing the levels of epistasis and pleiotropy.
Introduction: Spheno-orbital meningiomas (SOMs) represent a distinct subtype of meningioma characterized by their unique multi-compartmental invasion pattern. Previous studies have investigated correlations between SOMs and visual manifestations. However, our comprehension of pain associated with SOMs remains limited.
Background: The spina musculi recti lateralis (SMRL) is often visible along the lateral rim of the superior orbital fissure (SOF). Aim of this study is to characterize SMRL morphology and topography relative to known bony landmarks.
Methods: Orbits from 291 adult dry skulls and from 60 CT scans were analyzed to measure the distance between the SMRL and the SOF or the inferior orbital fissures (IOF) as well as its height, width and orientation.
Hydrogen Energy Technology Innovation Center of Hubei Province, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China. Electronic address:
Excellent porosity and accessibility are key requirements during carbon-based materials design for energy conversion applications. Herein, a Ni-based porous supramolecular framework with graphite-like morphology (Ni-SOF) was rationally designed as a carbon precursor. Ultrathin carbon nanosheets dispersed with Ni nanoparticles and Ni-N sites (Ni@NiN-N-C) were obtained via in-situ exfoliation during pyrolysis.
