Glucocorticoids are often used long-term at low doses (often 5 mg/day prednisolone or less), but it is still unclear how much we should worry about this. This article provides an indication of the prevalence of such use, discusses the current state of knowledge about the balance of benefit and harm, and provides some suggestions. At this time long-term low dose glucocorticoid therapy appears acceptable under suitable precautions in cases where good alternatives are lacking.
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