AI Article Synopsis
- This literature scoping review evaluates current infection prevention and control (IPC) methods for viral-mediated gene therapies and suggests a specific IPC strategy for healthcare settings.
- A team of experts analyzed articles published since 2009, focusing on five types of viral vectors, and found that specific disinfectants effectively inactivate some viruses, while others lacked sufficient research, especially on surface disinfection.
- The review emphasizes the urgent need for established IPC methods due to the rise of viral-mediated therapies, ultimately recommending a 1:10 solution of sodium hypochlorite for effective germicidal activity in clinical settings.
Article Abstract
Objective: This comprehensive literature scoping review outlines available infection prevention and control (IPC) methods for viral-mediated gene therapies and provides one IPC strategy for the healthcare setting based on a single-center recommendation.
Methods: A team of experts in pharmacy, healthcare epidemiology, and biosafety with experience in viral-mediated gene therapy was assembled within a pediatric hospital to conduct a comprehensive literature scoping review. The comprehensive review included abstracts and full-text articles published since 2009 and utilized prespecified search terms of the five viral vectors of interest: adenovirus (AV), retrovirus (RV), adeno-associated virus (AAV), lentivirus (LV), and herpes simplex virus (HSV). Case reports, randomized controlled trials, and bench research studies were all included, while systematic reviews were excluded.
Results: A total of 4473 case reports, randomized control trials, and benchtop research studies were identified using the defined search criteria. Chlorine compounds were found to inactivate AAV and AV, while alcohol-based disinfectants were ineffective. There was a relative paucity of studies investigating surface-based disinfection for HSV, however, alcohol-based disinfectants were effective in one study. Ultraviolent irradiation was also found to inactivate HSV in numerous studies. No studies investigated disinfection for LV and RV vectors.
Conclusions: The need to define IPC methods is high due to the rapid emergence of viral-mediated gene therapies to treat rare diseases, but published clinical guidance remains scarce. In the absence of these data, our center recommends a 1:10 sodium hypochlorite solution in clinical and academic environments to ensure complete germicidal activity of viral-mediated gene therapies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10897728 | PMC |
| http://dx.doi.org/10.1017/ash.2024.1 | DOI Listing |
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