AI Article Synopsis
- Malignant tumor cells undergo changes in their shape and gene expression, especially involving cytoskeleton proteins that aid in invasion and spreading to other parts of the body.
- Microtubules, an essential part of the cytoskeleton, depend on posttranslational modifications like acetylation, particularly at lysine 40 on α-tubulin, which is linked to cancer metastasis.
- Noncoding RNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play a significant role in regulating the expression of acetylated tubulin, influencing the development and spread of various cancers.
Article Abstract
Malignant tumor cells go through morphological and gene expression alterations, including rearrangement of cytoskeleton proteins that promote invasion and metastasis. Microtubules form a major cytoskeleton component that plays a significant role in regulating multiple cellular activities and function depending on the presence of posttranslational modification (PTM). Acetylation is a type of PTM that generally occurs in the lysine 40 region of α-tubulin and is known to be critically associated with cancer metastasis. Current evidence demonstrates that noncoding RNAs, such as long noncoding RNA (lncRNA) and microRNA (or miRNA), which are correlated with gene regulation modulate the expression of acetylated tubulin in the development and metastasis of cancer. This review provides an overview about the role of lncRNA and miRNA in regulation of tubulin acetylation in various types of cancer.
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