Interest in learning dissemination and implementation (D&I) science is at an all-time high. As founding faculty and fellows of a new center focused on D&I science, we have found that non-specialist researchers and newcomers to D&I science often express confusion around the difference between the D and the I. Relatedly, they struggle to identify what their specific D&I projects target to impact public health within the amorphous "black box" that is the singular, loosely defined "research-to-practice gap." To improve conceptual clarity and enhance engagement with D&I science, we developed a graphic-the D&I Bridge-and an accompanying glossary of terms to use as a teaching and framing tool. The D&I Bridge depicts D&I science as bridging what we know from public health knowledge to what we do in public health practice with intention and equity, and it spans over four distinct, inter-related gaps: the public health supply gap, the public health demand gap, the methodological/scientific gap, and the expertise capacity gap. The public health supply gap is addressed by implementation strategies, whereas the public health demand gap is addressed by dissemination strategies. The methodological/scientific gap is addressed by producing generalizable knowledge about D&I, and the expertise capacity gap is addressed by developing the multi-disciplinary workforce needed to advance D&I. Initial practice feedback about the D&I Bridge has been positive, and this conceptualization of D&I science has helped inform our center's D&I training, D&I project consultations, and strategic planning. We believe the D&I Bridge provides a useful heuristic for helping non-specialists understand the differential scopes of various D&I science projects as well as specific gaps that may be addressed by D&I methods.
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http://dx.doi.org/10.1186/s43058-024-00558-z | DOI Listing |
Philos Trans A Math Phys Eng Sci
December 2024
Institute for Cross-Disciplinary Physics and Complex Systems (IFISC) UIB-CSIC, Campus Universitat Illes Balears, Palma de Mallorca 07122, Spain.
Quantum optical networks are instrumental in addressing the fundamental questions and enable applications ranging from communication to computation and, more recently, machine learning (ML). In particular, photonic artificial neural networks (ANNs) offer the opportunity to exploit the advantages of both classical and quantum optics. Photonic neuro-inspired computation and ML have been successfully demonstrated in classical settings, while quantum optical networks have triggered breakthrough applications such as teleportation, quantum key distribution and quantum computing.
View Article and Find Full Text PDFTrauma Violence Abuse
December 2024
College of Public Health, Department of Social Work, George Mason University, VA, USA.
Researchers are increasingly conducting research using primary source data involving observation of, and exposure to, violent extremist individuals, their acts, their online content, and the ideologies that they act in support of. Of concern is that this increased use of primary source material has not occurred alongside a serious investigation of the traumatic outcomes that may result from constant exposure to such materials within the process of conducting academic research. As such, the goal of this review is to conduct a rapid evidence assessment to identify (a) What theories currently exist that conceptualize trauma stemming from vicarious observation of extremist atrocities? (b) In what similar domains (if any) have researchers conceptualized the trauma that stems from vicarious observation of extremist atrocities? (c) What is the current evidence base for these theories? And (d) What are the immediate research needs to extend this research and support the research workforce? Articles were identified using search strings related to types of trauma, and relevant domains of work (e.
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February 2025
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Five series of new 1,3,4-thiadiazole hybrids were designed and synthesized as promising EGFR inhibitors. Three human cancer cell lines were employed for testing each hybrid's in vitro antiproliferative efficacy; colon HCT-116, liver HepG-2 and breast MCF-7 using MTT assay. Comparing compound 9a to the reference doxorubicin, 9a shown superior activity to that of Dox with respect to MCF-7 (IC 3.
View Article and Find Full Text PDFInt J Mol Med
March 2025
Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China.
Bupleurum, a Traditional Chinese Medicine (TCM) herb, is widely used in China and other Asian countries to manage chronic liver inflammation and viral hepatitis. Saikosaponin D (SSD), a triterpenoid saponin extracted from Bupleurum, exhibits extensive pharmacological properties, including anti‑inflammatory, antioxidant, anti‑apoptotic, anti‑fibrotic and anti‑cancer effects, making it a therapeutic candidate for numerous diseases. Clarifying the targets and molecular mechanisms underlying TCM compounds is essential for scientifically validating TCM's therapeutic roles in disease prevention and treatment, as well as for identifying novel therapeutic targets and lead compounds.
View Article and Find Full Text PDFPacing Clin Electrophysiol
December 2024
Servei de Cardiologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
Introduction: Right ventricular (RV) pacing can impair left ventricular function and cause heart failure, known as pacing-induced cardiomyopathy (PICM). Upgrade to cardiac resynchronization (CRT) is its usual treatment; recently left bundle branch area pacing (LBBAP) has emerged as a potential alternative. Deep septal pacing (DSP), a simplified alternative to LBBAP, is still able to achieve narrower paced QRS than during conventional RV pacing.
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