Despite having significant applications in the construction of controlled delivery systems with high anti-interference capability, to our knowledge dual-controlled molecular release has not yet been achieved based on small molecular/supramolecular entities. Herein, we report a dual-controlled release system based on coordination cages, for which releasing the guest from the cage demands synchronously altering the coordinative metal cations and the solvent. The cages, HgL and AgL, are constructed via coordination-driven self-assembly of a corannulene-based ligand. While HgL shows a solvent-independent guest encapsulation in all the studied solvents, AgL is able to encapsulate the guests in only some of the solvents, such as acetone-d, but will liberate the encapsulated guests in 1,1,2,2-tetrachloroethane-d. HgL and AgL are interconvertible. Thus, the release of guests from HgL in acetone-d can be achieved, but requires two separate operations, including metal substitutions and a change of the solvent. Dual-controlled systems as such could be useful in complicated molecular release process to avoid those undesired stimulus-responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899651 | PMC |
| http://dx.doi.org/10.1038/s42004-024-01128-z | DOI Listing |
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