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Melatonin attenuates BDE-209-caused spatial memory deficits in juvenile rats through NMDAR-CaMKⅡγ-mediated synapse-to-nucleus signaling.
Food Chem Toxicol
January 2025
Department of Occupational and Environmental Health, School of Public Health, Jinzhou Medical University, Jinzhou, Liaoning, PR China. Electronic address:
Flame retardant polybrominated diphenyl ethers (PBDEs) accumulate in human bodies through food and dust ingestion, and cause neurobehavioral deficits with obscure mechanism. We aimed to investigate NMDAR-CaMKⅡγ-mediated synapse-to-nuclear communication involved in BDE-209-induced cognitive impairment, and alleviation from exogenous melatonin. Decreased NMDAR subunits GluN2A and 2B, autophosphorylation of CaMKⅡα, and postsynaptic GluA1 trafficking were observed in the hippocampus of juvenile rats after maternal BDE-209 exposure.
View Article and Find Full Text PDF[Genetic analysis of two novel variants in a Chinese pedigree affected with intellectual disorder].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
December 2024
Key Laboratory of Precision Medicine and Testing of Wenzhou City, Clinical Laboratory of Wenzhou Central Hospital, Wenzhou, Zhejiang 325000, China.
Objective: To explore the clinical phenotype and genetic characteristics of two siblings with intellectual disability.
Methods: Clinical data and peripheral blood samples were collected from the proband, his younger sister and parents whom had presented at Wenzhou Central Hospital in February 2024. Low-coverage massively parallel copy number variation sequencing (CNV-seq) and whole exome sequencing (WES) were carried out for the family.
Mechanistic insights into retinoic-acid treatment for autism in the improvement of social behavior: Evidence from a multi omics study in rats.
Neuropharmacology
March 2025
Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China. Electronic address:
Background: Autism spectrum disorder (ASD) is a lifelong condition. It is characterized by complex etiologies, including disruptions in exogenous retinoic acid (RA) signaling, which may serve as an environmental risk factor. Targeting the RA pathway presents a promising therapeutic avenue, though the precise mechanisms remain to be elucidated.
View Article and Find Full Text PDFTandem HILIC-IMAC strategy for simultaneous N-glycoproteomics and phosphoproteomics in aging mouse brain.
J Chromatogr A
January 2025
Key Laboratory of Phytochemistry and Natural Medicines. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, PR China; Ganjiang Chinese Medicine Innovation Center, Nanchang, 330000, PR China.
Article Synopsis
- Abnormal glycosylation and phosphorylation are linked to brain aging, with their interactions influencing pathological processes, yet prior studies rarely examined both simultaneously.
- A new tandem HILIC-IMAC method was developed to analyze N-glycosylation and phosphorylation in mouse brains from two different ages, revealing a wealth of data including nearly 11,000 glycopeptides and phosphopeptides.
- Results indicated that aging affected glycoproteins related to cell adhesion and extracellular matrix, while phosphoproteins influenced microtubule dynamics and synaptic transmission, showing opposing expression trends in glycosylation and phosphorylation.
AMPA and NMDA Receptors in Hippocampus of Rats with Fluoride-Induced Cognitive Decline.
Int J Mol Sci
November 2024
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 Thorez Avenue, Saint-Petersburg 194223, Russia.
This experimental study was performed to evaluate the alterations in the expression of a few subunits composing glutamate AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) receptors in the hippocampal cells of Wistar rats in response to long-term fluoride (F) exposure. The animals were given water with background 0.4 (control), 5, 20, and 50 ppm F (as NaF) for 12 months.
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