AI Article Synopsis
- - The review aimed to explore the genetic links of three specific SNPs (Renin-rs16853055, AGT-rs3789678, and ACE-rs4305) with hypertension in preeclampsia, along with their connection to HIV infection.
- - Recent findings showed limited research on these SNPs and preeclampsia, with AGT-rs3789678 being significantly associated with gestational hypertension, while the others showed no strong links.
- - Conflicts exist regarding the influence of ethnicity on preeclampsia and hypertension associations with these SNPs, and certain AGT alleles are noted to be more common in HIV-positive preeclamptic women in South Africa compared to
Article Abstract
Purpose Of Review: The primary goal of this review article was to determine whether the three RAAS-associated SNPs, Renin-rs16853055, AGT-rs3789678 and ACE-rs4305 are genetically linked to the development of hypertension in preeclampsia. The secondary goal was to establish if there was a link between these SNPs and HIV infection.
Recent Findings: There is a paucity of findings related to the aforementioned SNPs and preeclampsia. There are no recent findings on the rs16853055 renin polymorphism. The rs3789678 angiotensinogen polymorphism correlated significantly with gestational hypertension. The rs4305 ACE polymorphism showed no significant association with the development of pregnancy-induced hypertension. There are conflicting findings when determining the relationship between ethnicity and the predisposition of preeclampsia and hypertension in relation to the discussed RAAS-associated SNPs. To date, the association between RAAS-associated SNPs and preeclamptic women co-morbid with HIV in South Africa has revealed that certain alleles of the AGT gene are more prominent in HIV-infected PE compared to normotensive pregnant HIV-infected women.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153260 | PMC |
| http://dx.doi.org/10.1007/s11906-023-01292-y | DOI Listing |
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Article Synopsis
- - The review aimed to explore the genetic links of three specific SNPs (Renin-rs16853055, AGT-rs3789678, and ACE-rs4305) with hypertension in preeclampsia, along with their connection to HIV infection.
- - Recent findings showed limited research on these SNPs and preeclampsia, with AGT-rs3789678 being significantly associated with gestational hypertension, while the others showed no strong links.
- - Conflicts exist regarding the influence of ethnicity on preeclampsia and hypertension associations with these SNPs, and certain AGT alleles are noted to be more common in HIV-positive preeclamptic women in South Africa compared to
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