AI Article Synopsis
- Epstein-Barr virus (EBV) seropositivity rates in children with multiple sclerosis (MS) are notably lower compared to adults, raising questions about EBV's necessity in MS development.
- A study analyzed 251 children with demyelination and found that when accounting for MOGAD (myelin oligodendrocyte glycoprotein-associated disease), over 90% of MS children had evidence of EBV infection.
- The results support EBV's significant role in the MS spectrum while highlighting different biological mechanisms between MS and MOGAD.
Article Abstract
Reported rates of Epstein-Barr virus (EBV) seropositivity in children meeting multiple sclerosis (MS) diagnostic criteria are considerably lower than those reported in adult-onset MS, putting in question a requisite role for EBV in MS development. As prior work preceded recognition of myelin oligodendrocyte glycoprotein-associated disease (MOGAD), we assessed viral serologies in 251 children with incident demyelination and prospectively ascertained diagnoses. When MOGAD was serologically accounted for, the prevalence of EBV infection among MS children exceeded 90%, whereas remote EBV infection was not associated with MOGAD risk. Together, these findings substantiate EBV's role across the MS spectrum, and support distinct pathobiological mechanisms in MS versus MOGAD. ANN NEUROL 2024;95:700-705.
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| http://dx.doi.org/10.1002/ana.26890 | DOI Listing |
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