A convenient, efficient and practical approach for the synthesis of -quinolyl phosphorothioates cheap TsCl promoted deoxygenative C2-H phosphorothiolation of quinoline -oxides with readily available triethylammonium ,-dialkylphosphorothioates was developed. The reaction performed well under transition-metal-free conditions at room temperature with a very short reaction time (10-20 min). Preliminary studies showed that the current transformation underwent a nucleophilic substitution process.
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| http://dx.doi.org/10.1039/d4ob00111g | DOI Listing |
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