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Role of microRNAs in neutrophil extracellular trap formation and prevention: Systematic narrative review.
Mol Cell Probes
December 2024
Institute of Human Genetics, Jena University Hospital, Jena, Germany. Electronic address:
Article Synopsis
- * A systematic review was conducted to identify and classify microRNAs (miRNAs) associated with NETosis, focusing on their mechanisms and potential therapeutic targets to reduce NET formation in diseases.
- * The study sifted through articles from PubMed and Google Scholar and identified 14 miRNAs involved in NETosis, with eight potentially targetable for therapy to suppress excessive NET formation.
Unraveling the relevance of SARS-Cov-2 infection and ferroptosis within the heart of COVID-19 patients.
Heliyon
September 2024
Department of Animal Sciences and Marine Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Background: The coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to a huge mortality rate and imposed significant costs on the health system, causing severe damage to the cells of different organs such as the heart. However, the exact details and mechanisms behind this damage are not clarified. Therefore, we aimed to identify the cell and molecular mechanism behind the heart damage caused by SARS-Cov-2 infection.
View Article and Find Full Text PDFNAMPT enhances LOX expression and promotes metastasis in human chondrosarcoma cells by inhibiting miR-26b-5p synthesis.
J Cell Physiol
September 2024
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Chondrosarcoma is a malignant bone tumor that emerges from abnormalities in cartilaginous tissue and is related with lung metastases. Nicotinamide phosphoribosyltransferase (NAMPT) is an adipocytokine reported to enhance tumor metastasis. Our results from clinical samples and the Gene Expression Omnibus data set reveal that NAMPT levels are markedly higher in chondrosarcoma patients than in normal individuals.
View Article and Find Full Text PDFExosomal miRNA-26b-5p from PRP suppresses NETs by targeting MMP-8 to promote diabetic wound healing.
J Control Release
August 2024
Department of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, Chongqing 400014, China. Electronic address:
The utilization of platelet-rich plasma (PRP) has exhibited potential as a therapeutic approach for the management of diabetic foot ulcers (DFUs). However, it is currently not well understood how the diabetic environment may influence PRP-derived exosomes (PRP-Exos) and their potential impact on neutrophil extracellular traps (NETs). This study aims to investigate the effects of the diabetic environment on PRP-Exos, their communication with neutrophils, and the subsequent influence on NETs and wound healing.
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