AI Article Synopsis
- A study on a methanol extract from fruiting bodies led to the discovery of six new triterpenoids and one new pulvinic acid derivative, in addition to five previously known compounds.
- The chemical structures of these compounds were determined using advanced techniques like NMR spectroscopy and HRESIMS, while the triterpenoids' absolute configuration was confirmed through circular dichroism.
- Two of the pulvinic acid derivatives showed significant potential in reducing IL-6 secretion and were found to downregulate the p-STAT3 protein, indicating their potential therapeutic effects.
Article Abstract
The phytochemical study of the fruiting body methanol extract led to the isolation of six new triterpenoids (-) and one new naphthalenoid pulvinic acid derivative (), together with five known compounds, including norbadione A (). Their structure was established from 1D and 2D NMR spectroscopy and HRESIMS analyses. The absolute configuration of the triterpenoids was determined by circular dichroism. The two pulvinic acid derivatives and , showing the highest activity in modulating IL-6 secretion, were tested for their effect on COX-2, STAT3, and p-STAT3 proteins; both compounds were able to downregulate p-STAT3.
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| http://dx.doi.org/10.1021/acs.jnatprod.3c01055 | DOI Listing |
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Article Synopsis
- A study on a methanol extract from fruiting bodies led to the discovery of six new triterpenoids and one new pulvinic acid derivative, in addition to five previously known compounds.
- The chemical structures of these compounds were determined using advanced techniques like NMR spectroscopy and HRESIMS, while the triterpenoids' absolute configuration was confirmed through circular dichroism.
- Two of the pulvinic acid derivatives showed significant potential in reducing IL-6 secretion and were found to downregulate the p-STAT3 protein, indicating their potential therapeutic effects.
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