The study of DNA methylation and gene expression and the diagnostic potential of in preeclampsia.

The objective was to elucidate the potential epigenetic regulatory mechanism in  expression in preeclampsia. promoter DNA methylation was evaluated in the placental tissue and blood of preeclamptic and normotensive pregnant women. and gene expression were assessed in placental tissue and peripheral blood mononuclear cells (PBMCs). Related microarray datasets in the Gene Expression Omnibus database were also analyzed. In placental tissue, despite expression downregulation, there was no significant change in methylation. In PBMCs, there was no significant alteration in expression, while hypomethylation was observed in blood. The expression increased in the placental tissue and in the PBMCs of preeclampsia. DNA methylation does not affect expression, while might be a biomarker for preeclampsia.