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| http://dx.doi.org/10.3389/fpubh.2024.1309499 | DOI Listing |
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Computational insights into maternal environmental pollutants and folate pathway regulation.
Reprod Toxicol
December 2024
Department of Genomic Research, Sri Sathya Sai Sanjeevani Research Foundation, Palwal, Haryana, India, 121102. Electronic address:
Exposure to environmental pollutants during pregnancy can adversely affect fetal growth and postnatal development. While numerous studies have explored the interaction between environmental toxic chemicals and the folate pathway, few have examined their inhibitory effects on key targets. This computational study identified 27 maternal environmental toxicants using the Comparative Toxicogenomics Database (CTD) and analyzed them to identify their targets.
View Article and Find Full Text PDFFrom cells to recapture rates: responses and recovery of a wild fish after an experimental exposure to a widely used herbicide.
Environ Sci Pollut Res Int
December 2024
EPHE-PSL, Sorbonne Université, CNRS, UMR 7619 METIS, 75005, Paris, France.
Freshwater environments are biodiversity hotspots under multiple pressures, including pesticide exposure. S-metolachlor, a widely used herbicide, can induce genotoxic, cytotoxic and physiological effects in captive fish, but we have a limited understanding of the effects of exposure to S-metolachlor in free-living vertebrates. We carried out an original field experiment using integrative approaches across biological levels and temporal scales.
View Article and Find Full Text PDFPrevalence of fungal colonization among patients with psoriasis in difficult-to-treat areas: impact of apremilast on mycotic burden and clinical outcomes.
Front Immunol
December 2024
Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Introduction: Fungi, including , may be a trigger or exacerbate psoriasis, especially in difficult to treat (DTT) areas, through the activation of IL-17/23 axis.
Methods: In this study, seventy patients with DDT psoriasis were enrolled to evaluate species and/or other opportunistic fungi colonization rate at baseline (T0) and the impact of apremilast on fungal load, clinical outcome, serum cytokine levels and biochemical serum profile of patients after 16, 24 and 52 weeks of treatment.
Results: In our population, 33 (47%) patients were colonized by spp.
Influence of agarose in semi-IPN hydrogels for sustained Polymyxin B release.
Colloids Surf B Biointerfaces
December 2024
Laboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca, Chile. Electronic address:
Hydrogels (HGs) are 3-D polymeric networks with high water content, making them appropriate for biomedical applications such as drug delivery systems. This study examines the impact of agarose in semi-interpenetrating polymer networks (Semi-IPNs) based on poly(acrylic acid) (p(AA)), N, N' Methylenebis(acrylamide) (MBA) and agarose (AGA) on the sustained release of Polymyxin B (PolB). Agarose incorporation improved the mechanical strength, swelling behavior and drug retention capacity of the HG.
View Article and Find Full Text PDFExposure to Environmental Pollutants and Risk of Diarrhea: A Systematic Review.
Environ Health Insights
November 2024
African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, Choba, Nigeria.
This systematic review investigates the association between environmental pollutants and the risk of diarrhea, a critical public health issue, particularly in low- and middle-income countries. The review synthesizes findings from various studies that highlight the impact of contaminants such as pesticides, heavy metals, polycyclic aromatic hydrocarbons (PAHs), microplastics, and parabens on gastrointestinal health. Following PRISMA guidelines, a comprehensive literature search across databases including PubMed, Scopus, and Google Scholar yielded 496 articles, of which 11 met the inclusion criteria for detailed analysis.
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