AI Article Synopsis
- - The study introduces a new method for oxyaminating alkenes using sulfonamides, facilitated by WODipic(HO), resulting in high yields and selectivity for various types of alkenes.
- - A detailed catalytic cycle is proposed, which includes the formation of a tungstenooxaziridine complex as the active catalyst, with hydrolysis of a tungstenooxazolidine intermediate being the slowest step.
- - Initial experiments on kinetics and competition support the validity of the proposed mechanism behind this oxyamination reaction.
Article Abstract
Herein we report the WODipic(HO) promoted oxyamination of alkenes using sulfonamides as the quantitative source of . The reaction works for activated and unactivated alkenes in high yields, diastereoselectivities, and stereospecificity. A catalytic cycle involving the formation of tungstenooxaziridine complex 1 as the active catalyst and hydrolysis of tungstenooxazolidine intermediate as the rate-determining-step has been proposed. Initial kinetic and competition experiments provide evidence for the proposed mechanism.
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| http://dx.doi.org/10.1039/d4ob00022f | DOI Listing |
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