Anxiety and depression are two of the most common mental disorders worldwide, with a lifetime prevalence of up to 30%. These disorders are complex and have a variety of overlapping factors, including genetic, environmental, and behavioral factors. Current pharmacological treatments for anxiety and depression are not perfect. Many patients do not respond to treatment, and those who do often experience side effects. Animal models are crucial for understanding the complex pathophysiology of both disorders. These models have been used to identify potential targets for new treatments, and they have also been used to study the effects of environmental factors on these disorders. Recent proteomic methods and technologies are providing new insights into the molecular mechanisms of anxiety disorder and depression. These methods have been used to identify proteins that are altered in these disorders, and they have also been used to study the effects of pharmacological treatments on protein expression. Together, behavioral and proteomic research will help elucidate the factors involved in anxiety disorder and depression. This knowledge will improve preventive strategies and lead to the development of novel treatments.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-3-031-50624-6_6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Validation of the somatic symptom disorder-B Criteria Scale (SSD-12) in Bangladesh.
PLoS One
January 2025
Department of Clinical Psychology, University of Dhaka, Bangladesh.
Background: The absence of a reliable and valid Bangla instrument for measuring somatic symptom disorder hinders research and clinical activities in Bangladesh. The present study aimed at translating and validating the Somatic Symptom Disorder-B criteria (SSD-12).
Method: A cross-sectional design was used with purposively selected clinical (n = 100) and non-clinical (n = 100) samples.
Ventral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict.
PLoS Biol
January 2025
Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.
Successful resolution of approach-avoidance conflict (AAC) is fundamentally important for survival, and its dysregulation is a hallmark of many neuropsychiatric disorders, and yet the underlying neural circuit mechanisms are not well elucidated. Converging human and animal research has implicated the anterior/ventral hippocampus (vHPC) as a key node in arbitrating AAC in a region-specific manner. In this study, we sought to target the vHPC CA1 projection pathway to the nucleus accumbens (NAc) to delineate its contribution to AAC decision-making, particularly in the arbitration of learned reward and punishment signals, as well as innate signals.
View Article and Find Full Text PDFEfficacy of videoconferencing-delivered cognitive behavioural therapy to reduce anxiety disorder severity in LGBTQ+ people: An exploratory trial protocol.
PLoS One
January 2025
Discipline of Clinical Psychology, Graduate School of Health, University of Technology, Sydney, New South Wales, Australia.
Objective: Cognitive behavior therapy (CBT) is a well-established treatment for anxiety disorders in the general population. However, the efficacy of CBT for lesbian, gay, bisexual, transgender, queer, questioning, and otherwise non-heterosexual or non-cisgender (LGBTQ+) people with anxiety disorders is still emerging in the literature. This protocol proposes an exploratory, two-group, randomized controlled trial comparing the efficacy of CBT for anxiety disorders against a waitlist control group.
View Article and Find Full Text PDFThe effects of the SARS-CoV-2 pandemic on self-reported interoception and mental health.
PLoS One
January 2025
Department of Psychology, University of Surrey, Guildford, United Kingdom.
Background: Atypical interoception has been observed across multiple mental health conditions, including anxiety disorders and depression. Evidence suggests that not only pathological anxiety, but also heightened levels of state anxiety and stress are associated with interoceptive functioning. This study aimed to investigate the effects of the recent Coronavirus SARS-CoV-2 pandemic on self-reported interoception and mental health, and their relationship.
View Article and Find Full Text PDFAssessing the efficacy of psychological interventions in enhancing the quality of life of patients diagnosed with cancer and psychiatric disorders: An umbrella analysis.
Adv Clin Exp Med
January 2025
Department of Oncology, Shengjing Hospital of China Medical University, China.
Background: Psychosocial interventions encompass psychotherapy and psychological education that explicitly target psychosocial adaptation. These interventions have been shown to have a substantial positive effect on reducing anxiety and depression, as well as improving overall quality of life (QoL). Nevertheless, there is still no consensus concerning the therapeutic effectiveness of these interventions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!