Polycyclic aromatic hydrocarbons (PAHs) are major organic pollutants attached to fine particulate matter in the atmosphere. They induce lung inflammation, asthma, and other lung diseases. Exploring the toxic mechanism of PAHs on lung epithelial cells may provide a theoretical basis for the prevention and treatment of respiratory diseases induced by PAHs. In our study, 16 human bronchial epithelial (16HBE) cells were exposed to different concentrations of gypsum dust, Benzo(a)pyrene (BaP), and BaP-loaded gypsum dust for 24 hours. Gypsum dust loaded with BaP significantly increased the cytotoxicity of 16HBE cells, enhanced the production of lactate dehydrogenase (LDH), interleukin-6 (IL-6) and interleukin-8 (IL-8), induced cell apoptosis, and upregulate the expression of hsa_circ_0008500 (circ_0008500). The mechanism was studied with a BaP-loaded gypsum dust concentration of 1.25 mg/mL. StemRegenin 1 (SR1) pretreat significantly reduced the release of LDH, IL-6, and IL-8 and decreased the protein levels of Ahr、XAP2, C-myc, and p53. Second-generation sequencing indicated that circ_0008500 was highly expressed after 16HBE induced by BaP-loaded gypsum dust. Functional experiments confirmed that circ_0008500 promoted the inflammation and apoptosis of 16HBE cells induced by BaP-loaded gypsum dust by regulating the Ahr signaling pathway. Our study showed that fine particulate matter adsorption of BaP significantly increased the toxic effect of BaP on cells. By activating the Ahr/C-myc pathway, circ_0008500 promoted inflammation and apoptosis of 16HBE cells induced by BaP-loaded gypsum dust.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.toxlet.2024.02.003 | DOI Listing |
J Hazard Mater
January 2025
Institute of Environmental Assessment and Water Research (IDAEA). Spanish National Research Council (CSIC), C/Jordi Girona, 18-26, Barcelona 08034, Spain. Electronic address:
This study investigates arsenic (As) species, sources, and transformation patterns in deposited coal mine dust (DCMD) from three coal mines-QSY, MHJ, and SCC-in the Ningdong Coalfield, China. While the parent coals have low As levels, the DCMD shows significant enrichment, with concentrations 137 to 345 times higher. The mineral composition of the DCMD reflects that of the parent coals but includes secondary minerals such as gypsum and various trace elements, including As.
View Article and Find Full Text PDFSci Rep
November 2024
School of Civil Engineering, Liaoning Technical University, Fuxin, 123000, People's Republic of China.
To address the low utilization rate and environmental pollution of mine tailings (MT) and cement kiln dust (CKD), a CKD-based cemented paste backfill (CPB) material was prepared using quicklime (CaO) and sulfate (DH-7) as a composite alkaline activator (CAA), with CKD and slag as the cementitious material and MT as the aggregate. The optimal dosage of the new CAA was determined through unconfined compressive strength (UCS) analysis. The reaction products, pore structure, and cation dissolution ability of CKD-based CPB activated by CAA were investigated, analyzing the mechanism of strength enhancement.
View Article and Find Full Text PDFACS EST Air
November 2024
Department of Chemistry and Molecular Biology, Atmospheric Science, University of Gothenburg, SE-41390 Gothenburg, Sweden.
Dust storms in arid regions transport desert salts and dust, affecting geochemical processes, atmospheric chemistry, climate, and human health. This study examines how the gas-salt interface composition of desert salt changes with varying relative humidity (RH), using ambient pressure X-ray photoelectron spectroscopy (APXPS), near-edge X-ray absorption fine structure (NEXAFS) spectroscopy, and molecular dynamics (MD) simulations. Ion chromatography analysis of desert salt indicates it is predominantly composed of sulfate, sodium, and magnesium ions, with traces of calcium, chloride, nitrate, and potassium ions.
View Article and Find Full Text PDFJ Environ Sci (China)
April 2025
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China; National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Guangdong Institute of Eco-environmental Science & Technology, Guangdong Academy of Sciences, Guangzhou 510650, China. Electronic address:
Braz J Biol
August 2024
Universidade Federal de Pelotas - UFPel, Instituto de Biologia, Departamento de Ecologia de Insetos, Zoologia e Genética, RS, Brasil.
The maize weevil, Sitophilus zeamais Motschulsky, 1855 (Coleoptera: Curculionidae), generally reaches pest status in stored grain. Chemical control is the most used method for population suppression, which can cause adverse impacts, thus creating a need for alternatives such as using inert powders. The present work aims to verify the effect of different concentrations of different types of inert powders on the mortality of S.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!