Ivermectin was evaluated against natural and artificial pinworm (Syphacia) infections in mice. Ivermectin given in the diet for 6 days at 0.0005% was 99% effective against both immature and adult worms. A diet level of 0.0004% reduced immature and mature pinworm by 99 and 75%, respectively but 0.0001% was inactive. One oral dose of 2.0 mg/kg was 100 and 97% effective against gravid females and immature worms, respectively. A dose of 1.0 mg/kg was 96 and 66% effective against the same parasitic stages. A similar effect was observed against adult male worms where 94 and 86% were removed by one oral dose of ivermectin at 2.0 and 1.0 mg/kg, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1017/s0022149x00008051 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Case report: C57BL/6NTac and C57BL/6NCrl mice displaying neurological signs after deworming with ivermectin.
Lab Anim
December 2024
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
For over 40 years, ivermectin has served as an effective anti-parasitic drug used in human and veterinary medicine. In laboratory animal facilities it is used prophylactically or therapeutically to maintain the health status of the colony or experimentally in studies. Although ivermectin is generally safe to use, there are reports of neurotoxicity associated with ivermectin crossing the blood-brain barrier due to overdosing or blood-brain barrier dysfunction.
View Article and Find Full Text PDFPharmacoproteomics reveals energy metabolism pathways as therapeutic targets of ivermectin in ovarian cancer toward 3P medical approaches.
EPMA J
December 2024
Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, Shandong 250117 People's Republic of China.
Article Synopsis
- Ovarian cancer has the highest mortality rate among female reproductive system cancers, and there is a pressing need for effective treatments like ivermectin, which has shown promise in previous studies for inhibiting cancer cell growth and affecting energy metabolism.
- Researchers created a mouse model to study how ivermectin works in vivo, using proteomic analysis to identify and analyze significant protein changes in tumor tissues from different treatment groups.
- Results indicated that ivermectin led to a 61.5% tumor inhibition rate, with molecular changes in the tumor tissue highlighting energy metabolic pathways as key factors in its therapeutic effects.
Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway.
Acta Biochim Biophys Sin (Shanghai)
November 2024
Epigenetics & Translational Medicine Laboratory, School of Life Sciences, Henan University, Kaifeng 475004, China.
Esophageal squamous cell carcinoma (ESCC) is one of the most common forms of malignancy worldwide. However, there is currently a lack of effective chemotherapeutic drugs for ESCC. Ivermectin is a broad-spectrum antiparasitic drug with notable antitumor activity.
View Article and Find Full Text PDFSelenium protects mouse spermatogonia against ivermectin-induced apoptosis by alleviating endoplasmic reticulum stress in vitro.
Ecotoxicol Environ Saf
November 2024
Department of Animal Science and Technology, Chung-Ang University, Anseong-Si, Gyeonggi-Do 17546, Republic of Korea. Electronic address:
Ivermectin (IVM) is a widely used anthelmintic in human and veterinary medicine. However, the increasing use of IVM raises concerns about its potential harm against non-targeted organisms. This study demonstrates a novel mechanism where IVM triggers apoptosis via endoplasmic reticulum (ER) stress in GC-1 spg in vitro.
View Article and Find Full Text PDFInhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis-like lesions.
Int Immunopharmacol
December 2024
State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing 210093, PR China. Electronic address:
Article Synopsis
- * Using ivermectin, which inhibits KPNA2, significantly improved psoriasis symptoms in mice by reducing redness, scaling, and thickness of the skin, alongside lower levels of KPNA2 and markers of skin cell growth.
- * The research also showed that reducing KPNA2 affected key signaling pathways in skin cells, suggesting it plays a crucial role in the development of psoriasis and could be a viable target for new treatments in the future.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!