AI Article Synopsis
- A 44-year-old woman with a history of gastric cancer and fundic gland polyposis was referred for diagnosis and treatment, having previously been treated for Helicobacter pylori infection.
- After years of monitoring, she developed fundic gland polyps that increased in size, leading to suspicion of a genetic disorder known as GAPPS.
- A robotic total gastrectomy was performed, revealing gastric cancer without lymph node metastasis, highlighting how gastric phenotypes may vary with H. pylori infection status.
Article Abstract
A 44-year-old woman with gastric cancer (GC) and fundic gland polyposis (FGPs) was referred to our hospital for further diagnosis and treatment. She successfully underwent eradication therapy for Helicobacter pylori (HP) 6 years ago, but did not exhibit FGPs at that time. When she underwent an esophagogastroduodenoscopy 2, 4, and 5 years after the eradication of HP, her imaging results revealed the existence of FGPs which gradually increased in her gastric fundus and body. Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) was suspected and a mutational analysis was performed, revealing an APC promoter 1B variant c.-191T > C. A robotic total gastrectomy with lymphadenectomy was performed. Histopathological analysis of the surgical specimens revealed GC with no lymph node metastasis. GAPPS is characterized by GC and FGPs. However, our case shows different gastric phenotypes that are dependent on the status of HP infection.
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| http://dx.doi.org/10.1007/s10120-024-01473-x | DOI Listing |
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