Forty-one cases of dermatofibrosarcoma protuberans are presented. The clinical features and histopathological appearances are described. Immunohistochemical staining of thirteen cases with antisera to lysozyme, alpha 1-antichymotrypsin and S-100 protein has provided no evidence to support either a histiocytic or neuroectodermal origin for these tumours. In reviewing the literature, the histogenetic origin, differential diagnosis and malignant potential of dermatofibrosarcoma protuberans are discussed.
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Article Synopsis
- Dermatofibrosarcoma protuberans (DFSP) is a rare type of low-grade cancer that can be difficult to diagnose.
- It often looks similar to benign skin lesions, which can lead to confusion in diagnosis.
- Prompt recognition and differentiation from other skin conditions are important for effective treatment.
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