AI Article Synopsis
- Researchers tested whether low-dose interleukin 2 (IL-2) could increase the number and function of neuroprotective regulatory T cells (Tregs) in a model of Parkinson's disease.
- The study found that IL-2 treatment for 5 days significantly boosted the population of specific Tregs in mice, leading to improved survival of dopaminergic neurons affected by toxin exposure.
- These findings suggest that IL-2 may serve as a promising approach to enhance neuroprotection in neurodegenerative disorders like Parkinson's disease by boosting protective Treg levels.
Article Abstract
Background: Pharmacological approaches that boost neuroprotective regulatory T cell (Treg) number and function lead to neuroprotective activities in neurodegenerative disorders.
Objectives: We investigated whether low-dose interleukin 2 (IL-2) expands Treg populations and protects nigrostriatal dopaminergic neurons in a model of Parkinson's disease (PD).
Methods: IL-2 at 2.5 × 10 IU/dose/mouse was administered for 5 days. Lymphocytes were isolated and phenotype determined by flow cytometric analyses. To 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxicated mice, 0.5 × 10 of enriched IL-2-induced Tregs were adoptively transferred to assess the effects on nigrostriatal neuron survival.
Results: IL-2 increased frequencies of CD4CD25CD127FoxP3 Tregs that express ICOS and CD39 in blood and spleen. Adoptive transfer of IL-2-induced Tregs to MPTP-treated recipients increased tyrosine hydroxylase (TH) nigral dopaminergic neuronal bodies by 51% and TH striatal termini by 52% compared to control MPTP-treated animal controls.
Conclusions: IL-2 expands numbers of neuroprotective Tregs providing a vehicle for neuroprotection of nigrostriatal dopaminergic neurons in a pre-clinical PD model.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254387 | PMC |
| http://dx.doi.org/10.1515/nipt-2022-0001 | DOI Listing |
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