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| http://dx.doi.org/10.1111/jgs.18823 | DOI Listing |
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Study Objectives: Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep macro-architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium (SDC).
View Article and Find Full Text PDFThe association of agricultural and non-agricultural work on the healthy ageing of older adults in Japan: A 6-year longitudinal study from the Japan Gerontological evaluation study.
Prev Med Rep
January 2025
Department of Community Building for Well-being, Center for Preventive Medical Sciences, Chiba University, Chiba-shi, Chiba, Japan.
Objectives: Many studies have examined the impact of employment on health, but few large-scale longitudinal studies specifically investigate the impact of agricultural labor on the health of older adults. This study aims to identify the health effects of employment on older Japanese adults, focusing on agricultural workers.
Methods: This study uses longitudinal data collected by the Japan Gerontological Evaluation Study (JAGES) from 2013 to 2019.
Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer's disease.
Brain Commun
December 2024
Division of Psychiatry, University College London, London W1T 7NF, UK.
Hyperphosphorylated tau accumulation is seen in the noradrenergic locus coeruleus from the earliest stages of Alzheimer's disease onwards and has been associated with symptoms of agitation. It is hypothesized that compensatory locus coeruleus-noradrenaline system overactivity and impaired emotion regulation could underlie agitation propensity, but to our knowledge this has not previously been investigated. A better understanding of the neurobiological underpinnings of agitation would help the development of targeted prevention and treatment strategies.
View Article and Find Full Text PDFThe association between dual sensory impairment and dementia: A systematic review and meta-analysis.
J Alzheimers Dis
January 2025
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Background: Sensory impairments have been linked to dementia. However, the impact of dual sensory impairment (DSI), combining both vision impairment and hearing impairment, on dementia has shown inconsistent results.
Objective: To systematically review the evidence on the association DSI and dementia.
Neighborhood environment associations with cognitive function and structural brain measures in older African Americans.
BMC Med
January 2025
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Background: Since older adults spend significant time in their neighborhood environment, environmental factors such as neighborhood socioeconomic disadvantage, high racial segregation, low healthy food availability, low access to recreation, and minimal social engagement may have adverse effects on cognitive function and increase susceptibility to dementia. DNA methylation, which is associated with neighborhood characteristics as well as cognitive function and white matter hyperintensity (WMH), may act as a mediator between neighborhood characteristics and neurocognitive outcomes.
Methods: In this study, we examined whether DNA methylation in peripheral blood leukocytes mediates the relationship between neighborhood characteristics and cognitive function (N = 542) or WMH (N = 466) in older African American (AA) participants without preliminary evidence of dementia from the Genetic Epidemiology Network of Arteriopathy (GENOA).
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