Herein, we report the catalytic allylic amination of α-methylalkenes with VODipic(HMPA) and chloramine T as the quantitative source of . The reaction works with high yields and stereoselectivities for α-methylalkenes. A proposed tosylnitrene-free catalytic cycle involving the formation of vanadoxaziridine complex as the active catalyst and aminovanadation across the substrate as the rate-determining step has been proposed. Initial kinetic and competition experiments provide evidence for the proposed mechanism.
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| http://dx.doi.org/10.1021/acs.joc.3c02859 | DOI Listing |
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