The Editor-in-Chief and Deputy Editor of announce the prize for the best paper published in the Journal between 2020 and 2022.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890871 | PMC |
| http://dx.doi.org/10.1364/BOE.519386 | DOI Listing |
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Preparation, mechanism, and biological applications of targeting LDs ratiometric fluorescent probes for HClO detection.
Anal Chim Acta
February 2025
Institute of Environmental Science, Shanxi University, Taiyuan 030006, China.
Hypochlorous acid (HClO) is a well-known inflammatory signaling molecule, while lipid droplets (LDs) are dynamic organelles closely related to inflammation. Using organic small-molecule fluorescence imaging technology to target LDs for precise monitoring of HClO is one of the most effective methods for diagnosing inflammation-related diseases. A thorough investigation of how probes detect biological markers and the influencing factors can aid in the design of probe molecules, the selection of high-performance tools, and the accuracy of disease detection.
View Article and Find Full Text PDFUse of design thinking to develop a benchmarking tool to assess documentation procedures in a hospital pharmacy aseptic compounding unit: a case study.
Eur J Hosp Pharm
January 2025
School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland
Objectives: This paper combines the concepts of design thinking and benchmarking in an aseptic manufacturing context. Design thinking is a problem-solving approach that aims to understand user needs, generate ideas, prototypes and test solutions. There are no published examples in the Irish healthcare setting.
View Article and Find Full Text PDFFactors and mechanisms driving among-lake variability of mercury concentrations in a benthivorous fish in the Canadian subarctic.
Chemosphere
January 2025
Department of Biology, Wilfrid Laurier University, Waterloo, ON, Canada. Electronic address:
Wild-caught fish are an important subsistence food source in remote northern regions, but they can also be a source of exposure to mercury (Hg), which has known health hazards. We investigated factors and mechanisms that control variability of Hg concentrations in Lake Whitefish (Coregonus clupeaformis) among remote subarctic lakes in Northwest Territories, Canada. Integrating variables that reflect fish ecology, in-lake conditions, and catchment attributes, we aimed to not only determine factors that best explain among-lake variability of fish Hg, but also to provide a whole-ecosystem understanding of interactions that drive among-lake variability of fish Hg.
View Article and Find Full Text PDFBackground: The increased use of chemicals leads to a continuous deposition of chemicals in the environment and to a continuous increase in exposure of the global and the European population. Comprehensive burden of disease analyses are however still missing for many countries.
Methods: Using the World Health Organization's Environmental Burden of Disease (EBD) approach and combining data from the European Human Biomonitoring (HBM) dashboard with disease and population data, we estimated the comprehensive attributable burden (AB) for the year 2021, in the best-case quantified by disability-adjusted life years (DALY).
Elucidating on the Quaternary Structure of Viper Venom Phospholipase A Enzymes in Aqueous Solution.
Biochimie
January 2025
LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal. Electronic address:
This study focuses on the quaternary structure of the viper-secreted phospholipase A (PLA), a central toxin in viper envenomation. PLA enzymes catalyse the hydrolysis of the sn-2 ester bond of membrane phospholipids. Small-molecule inhibitors that act as snakebite antidotes, such as varespladib, are currently in clinical trials.
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