Prosthetic joint infection following total joint arthroplasty is a devastating complication, resulting in increased morbidity and mortality for the patient. The formation of a biofilm on implanted hardware contributes to the difficulty in successful identification and eradication of the infection. Antibiotic therapy and surgical intervention are necessary for addressing this condition; we present a discussion on different treatment options, including those that are not yet routinely utilized in the clinical setting or are under investigation, to highlight the present and future of PJI management.
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http://dx.doi.org/10.1016/j.ocl.2023.10.001 | DOI Listing |
Sci Rep
December 2024
Department of Orthopedic Surgery, The First Hospital of Hebei Medical University, NO. 89 Donggang Road, Shijiazhuang, 063000, Hebei, P. R. China.
The risks and benefits associated with simultaneous bilateral unicompartmental knee arthroplasty (UKA) continue to engender contentious debate. The aim of this study was to compare the clinical outcomes of simultaneous bilateral and unilateral UKA. A retrospective review was performed between 2019 and 2022 on 280 patients (130 simultaneous bilateral vs.
View Article and Find Full Text PDFJ Bone Joint Surg Am
October 2024
Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Background: Pelvic reconstruction after type I + II (or type I + II + III) internal hemipelvectomy with extensive ilium removal is a great challenge. In an attempt to anatomically reconstruct the hip rotation center (HRC) and achieve a low mechanical failure rate, a custom-made, 3D-printed prosthesis with a porous articular interface was developed. The aim of this study was to investigate the clinical outcomes of patients treated with this prosthesis.
View Article and Find Full Text PDFmBio
December 2024
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Unlabelled: The bacterium is an opportunistic pathogen that can cause lung, skin, wound, joint, urinary tract, and eye infections. While is known to exhibit a robust competitive response toward other bacterial species, this bacterium is frequently identified in polymicrobial infections where multiple species survive. For example, in prosthetic joint infections, can be identified along with other pathogenic bacteria including , , and .
View Article and Find Full Text PDFPerm J
December 2024
School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Introduction: Hip hemiarthroplasty is a surgical procedure that requires the adhesion of the prosthetic implant by utilizing a fixation technique, either cemented or noncemented. The current literature does not provide a clear recommendation on a superior technique, although many countries outside the US have guidelines recommending cemented over noncemented procedures. Further, surgeon perceptions and beliefs related to the cemented and noncemented techniques in hip arthroplasty fractures are generally unknown.
View Article and Find Full Text PDFClin Orthop Relat Res
October 2024
Rush Copley Medical Center, Aurora, IL, USA.
Background: Polymethylmethacrylate (PMMA) antibiotic-laden bone cement (ALBC) is commonly used in total joint arthroplasty to treat and potentially prevent prosthetic joint infection (PJI). Multiple properties impact the elution characteristics of antibiotics from PMMA-based ALBC, including viscosity. What is not known is how medium-viscosity cement formulations affect antibiotic elution and how different cement products from different manufacturers compare regarding reaching the minimum inhibitory concentration (MIC) of antibiotics for common PJI-causing organisms in an in vitro setting.
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