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Event-driven PrEP beyond cisgender men who have sex with men.
Lancet HIV
January 2025
Division of Infectious Diseases, Hennepin Healthcare, Minneapolis, MN, USA; University of Minnesota, Minneapolis, MN, USA. Electronic address:
Despite advancements in existing antiretroviral-based prevention strategies, including daily oral, locally acting, and injectable options, there is a pressing need for more inclusive and flexible event-driven pre-exposure prophylaxis (PrEP) strategies for all. Event-driven or intermittent dosing of PrEP in populations beyond cisgender men who have sex with men would offer a promising alternative by fitting prevention into the diverse lifestyles of affected populations and thereby advancing health equity. Evidence from PrEP clinical trials, pharmacokinetic studies, modelling studies, and real-world observational research suggests that event-driven PrEP could be a flexible and inclusive option, yet optimal dosing has not been established across sex and gender spectrums.
View Article and Find Full Text PDFPhosphorylation of 'SDT-like' motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression.
Open Biol
December 2024
Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Approximately 10-15% of human cancers are telomerase-negative and maintain their telomeres through a recombination-based process known as the alternative lengthening of telomeres (ALT) pathway. Loss of the alpha-thalassemia/mental retardation, X-linked (ATRX) chromatin remodeller is a common event in ALT-positive cancers, but is generally insufficient to drive ALT induction in isolation. We previously demonstrated that ATRX binds to the MRN complex, which is also known to be important in the ALT pathway, but the molecular basis of this interaction remained elusive.
View Article and Find Full Text PDFDelayed Ferumoxtran-10-Enhanced Magnetic Resonance Neurography of the Lumbosacral Plexus: Impact on Vascular Suppression and Image Quality.
J Magn Reson Imaging
September 2024
Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ), Zurich, Switzerland.
Background: Intravenous Ferumoxtran-10 belongs to ultra-small superparamagnetic iron oxide particles and can be used for magnetic resonance neurography (MRN) as an alternative to other imaging methods which use contrast agents.
Purpose: To examine the impact of intravenous Ferumoxtran-10 on vascular suppression and compare image quality to gadolinium (Gd)-enhanced image acquisition in MRN of lumbosacral plexus (LS).
Study Type: Prospective.
Head model dataset for mixed reality navigation in neurosurgical interventions for intracranial lesions.
Sci Data
May 2024
Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043, Marburg, Germany.
Article Synopsis
- Mixed reality navigation (MRN) technology is becoming an important tool in neurosurgery, allowing surgeons to visualize the brain using a mix of virtual and physical elements for better guidance during procedures.
- MRN is seen as a cost-effective and user-friendly alternative to traditional neuronavigation methods, but faces challenges like patient recruitment and the availability of affordable, medically relevant head models for research.
- To help advance the development of MRN systems, a new dataset has been created that includes imaging data and 3D models from 19 patients with brain lesions, which can be used for testing and improving MRN applications in surgery.
SEE ALTERNATE MRN: Duplicate charts in hospitalized patients.
J Hosp Med
September 2024
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
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