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Olfactory deficits in aging and Alzheimer's-spotlight on inhibitory interneurons.
Front Neurosci
December 2024
Institute of Physiology, RG Neurophysiology and Optogenetics, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany.
Cognitive function in healthy aging and neurodegenerative diseases like Alzheimer's disease (AD) correlates to olfactory performance. Aging and disease progression both show marked olfactory deficits in humans and rodents. As a clear understanding of what causes olfactory deficits is still missing, research on this topic is paramount to diagnostics and early intervention therapy.
View Article and Find Full Text PDFA generation at risk: the unseen consequences of Nepal's nursing shortage on undergraduate nursing students clinical education.
BMC Nurs
December 2024
School of Nursing and School of Public Health, Chitwan Medical College, Bharatpur-5, Kailashnagar, Chitwan, Nepal.
Background: The global nursing shortage has particularly severe consequences in resource-constrained countries like Nepal, where a significant outflow of healthcare professionals exacerbates the crisis. While the impact on patient care, workforce dynamics, and organizational challenges within healthcare settings have been extensively researched, the profound implications of this crisis for nursing education remain underexplored. This qualitative study sheds light on the often-unseen consequences of the nursing shortage on undergraduate nursing students' clinical education.
View Article and Find Full Text PDFLeptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss.
Metabolism
December 2024
Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA. Electronic address:
The dorsomedial hypothalamus (DMH) receives inputs from the preoptic area (POA), where ambient temperature mediates physiological adaptations of energy expenditure and food intake. Warm-activated POA neurons suppress energy expenditure via brown adipose tissue (BAT) projecting neurons in the dorsomedial hypothalamus/dorsal hypothalamic area (dDMH/DHA). Our earlier work identified leptin receptor (Lepr)-expressing, BAT-projecting dDMH/DHA neurons that mediate metabolic leptin effects.
View Article and Find Full Text PDFTranscatheter Pulmonary Flow Restrictors: Current Trends and Future Perspectives.
Catheter Cardiovasc Interv
January 2025
Pediatrics & Medicine, Weill Cornell Medicine Chief International Patients Services & Chair, Sidra Department Cardiovascular Diseases, University of Jordan, Amman, Jordan.
Article Synopsis
- Transcatheter Pulmonary Flow Restrictors (TPFRs) are innovative devices for managing pulmonary blood flow in congenital heart disease, yet there is a lack of detailed studies examining their variety and crucial design features.
- * The review consolidates current knowledge on TPFRs, highlights significant design considerations, identifies gaps in medical practice, and suggests future research avenues to improve these devices.
- * An analysis of 82 TPFR implants revealed challenges like complications with microvascular plugs, including issues with sizing, device migration, and thrombosis, while emphasizing the need for devices that can be safely removed and reduce risks like embolization and inflammation.
Research trends of cellular immunotherapy for primary liver cancer: A bibliometric analysis.
Hum Vaccin Immunother
December 2024
Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.
Article Synopsis
- - This study analyzed research trends in cellular immunotherapy for primary liver cancer (PLC), particularly focusing on hepatocellular carcinoma (HCC), using bibliometric methods and data from the Web of Science Core Collection.
- - Key findings highlighted China, Japan, and the USA as the top contributing countries, with Sun Yat-sen University producing the most publications and Li Zonghai being the leading author.
- - The analysis identified significant keywords like "CAR-T cells" and "liver transplantation" that gained attention over recent years, establishing a solid framework for understanding the evolving landscape of cellular immunotherapy for PLC.
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