Most tissues of the human body present hierarchical fibrillar extracellular matrices (ECMs) that have a strong influence over their physicochemical properties and biological behavior. Of great interest is the introduction of this fibrillar structure to hydrogels, particularly due to the water-rich composition, cytocompatibility, and tunable properties of this class of biomaterials. Here, the main bottom-up fabrication strategies for the design and production of hierarchical biomimetic fibrillar hydrogels and their most representative applications in the fields of tissue engineering and regenerative medicine are reviewed. For example, the controlled assembly/arrangement of peptides, polymeric micelles, cellulose nanoparticles (NPs), and magnetically responsive nanostructures, among others, into fibrillar hydrogels is discussed, as well as their potential use as fibrillar-like hydrogels (e.g., those from cellulose NPs) with key biofunctionalities such as electrical conductivity or remote stimulation. Finally, the major remaining barriers to the clinical translation of fibrillar hydrogels and potential future directions of research in this field are discussed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11209813PMC
http://dx.doi.org/10.1002/adhm.202303167DOI Listing

Publication Analysis

Top Keywords

fibrillar hydrogels
12
fibrillar
6
hydrogels
5
hierarchical design
4
design tissue-mimetic
4
tissue-mimetic fibrillar
4
fibrillar hydrogel
4
hydrogel scaffolds
4
scaffolds tissues
4
tissues human
4

Similar Publications

Hierarchical Collagen/Apatite Co-assembly for Injection of Mineralized Fibrillar Tissue Analogues.

ACS Biomater Sci Eng

December 2024

Sorbonne Université, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 4 place Jussieu, F-75005 Paris, France.

Mineralized biological tissues rich in type I collagen (e.g., bone and dentin) exhibit complex anisotropic suprafibrillar organizations in which the organic and inorganic moieties are intimately coassembled over several length scales.

View Article and Find Full Text PDF

Controlling the minimum gelation concentration (MGC) of low molecular weight (LMW) hydrogelators is a key for modulating gel properties, such as mechanical strength, viscoelasticity, and stability, which are crucial for applications ranging from drug delivery to tissue engineering. However, tweaking the MGC under specific conditions, such as pH and/or temperature, poses a considerable challenge. Herein, we varied the ionic strength of buffer solutions using NaCl for several LMW hydrogelators, including Fmoc-Phe, Fmoc-Tyr, Fmoc-Trp, Fmoc-Met, and Fmoc-Cha, and assessed their gelation efficiency at pH 7.

View Article and Find Full Text PDF

This study investigates the morphological, mechanical, and viscoelastic properties of bacterial cellulose (BC) hydrogels synthesized by the microbial consortium . BC gel films were produced under static (S) or bioreactor (BioR) conditions. Additionally, an anisotropic sandwich-like composite BC film was developed and tested, consisting of a rehydrated (S-RDH) BC film synthesized under static conditions, placed between two BioR-derived BC layers.

View Article and Find Full Text PDF

One of the key strategies for tissue engineering is to design multifunctional bioinks that balance printability with cytocompatibility. Here, we describe fibrillar hydrogels produced by Schiff base formation between B-type gelatin and oxidized sodium alginate, followed by the incorporation of type I collagen, yielding a new gel (MyoColl). The resulting hydrogel exhibits a temperature- and mass-ratio-dependent sol-gel transition, showing variability of hydrogel properties depending on the component ratio.

View Article and Find Full Text PDF
Article Synopsis
  • - Mixed-linkage glucans (MLGs) in plant cell-walls and cereals have been shown to gel quickly when cleaved by a specific enzyme (endo-β-glucanase), creating a low molecular-weight product that has a repeating structure.
  • - Research employing various techniques (rheology, microscopy, and X-ray scattering) revealed that the behavior of the material shifts from being like typical polymers to a more organized fibrillar network during digestion.
  • - The findings suggest that gelation occurs not by strengthening self-assembly interactions, but by removing interactions that prevent the assembly of MLG, as indicated by structural changes observed during the study.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!