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DENV-1 Titer Impacts Viral Blocking in Mel with Brazilian Genetic Background. | LitMetric

DENV-1 Titer Impacts Viral Blocking in Mel with Brazilian Genetic Background.

Viruses

Laboratório de Mosquitos Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.

Published: January 2024

AI Article Synopsis

Article Abstract

Several countries have been using deployments to replace highly competent native populations with -carrying mosquitoes with lower susceptibility to arboviruses such as dengue, Zika, and chikungunya. In Rio de Janeiro, deployments started in 2015 and still present a moderate introgression with a modest reduction in dengue cases in humans (38%). Here, we evaluated the vector competence of wild-type and Mel-infected with a Brazilian genetic background to investigate whether virus leakage could contribute to the observed outcomes in Brazil. We collected the specimens in three areas of Rio de Janeiro with distinct frequencies of mosquitoes with Mel strain and two areas with wild . The mosquitoes were orally exposed to two titers of DENV-1 and the saliva of DENV-1-infected was microinjected into Mel-free mosquitoes to check their infectivity. When infected with the high DENV-1 titer, the presence of Mel did not avoid viral infection in mosquitoes' bodies and saliva but DENV-1-infected Mel mosquitoes produced lower viral loads than Mel-free mosquitoes. On the other hand, Mel mosquitoes infected with the low DENV-1 titer were less susceptible to virus infection than Mel-free mosquitoes, although once infected, Mel and Mel-free mosquitoes exhibited similar viral loads in the body and the saliva. Our results showed viral leakage in 60% of the saliva of Mel mosquitoes with Brazilian background; thus, sustained surveillance is imperative to monitor the presence of other circulating DENV-1 strains capable of overcoming the blocking phenotype, enabling timely implementation of action plans.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10891765PMC
http://dx.doi.org/10.3390/v16020214DOI Listing

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