Dissolving microneedles (MNs) are novel transdermal drug delivery systems that can be painlessly self-administered. This study investigated the effects of experimental conditions on the mechanical characterization of dissolving MNs for quality evaluation. Micromolding was used to fabricate polyvinyl alcohol (PVA)-based dissolving MN patches with eight different cone-shaped geometries. Axial force mechanical characterization test conditions, in terms of compression speed and the number of compression needles per test, significantly affected the needle fracture force of dissolving MNs. Characterization using selected test conditions clearly showed differences in the needle fracture force of dissolving MNs prepared under various conditions. PVA-based MNs were divided into two groups that showed buckling and unbuckling deformation, which occurred at aspect ratios (needle height/base diameter) of 2.8 and 1.8, respectively. The needle fracture force of PVA-based MNs was negatively correlated with an increase in the needle's aspect ratio. Higher residual water or higher loading of lidocaine hydrochloride significantly decreased the needle fracture force. Therefore, setting appropriate methods and parameters for characterizing the mechanical properties of dissolving MNs should contribute to the development and supply of appropriate products.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10893124 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics16020200 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tellurium nanoparticles and Fucoidan-loaded dissolvable microneedles for combined photothermal therapy and anti-angiogenesis in melanoma treatment.
Int J Biol Macromol
December 2024
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:
Melanoma, an aggressive skin tumor, is prone to metastasis, significantly reducing patient survival rates once it occurs. Tumor microvascularity is a key factor in metastasis, making the inhibition of microvascular formation crucial. Emerging photothermal therapy (PTT) and microneedles (MNs) have garnered attention due to their non-invasive and controllable nature.
View Article and Find Full Text PDFDual-strategy microneedles of bio‑oxygen therapy and artificial enzyme anti-oxidation for psoriasis treatment.
Int J Biol Macromol
December 2024
Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Electronic address:
Oxidative stress results from an imbalance between the production of free radicals by oxidants and their removal by antioxidants. Chronic oxidative stress is a key factor in inflammation, characterized by hypoxic microenvironments and elevated levels of reactive oxygen species (ROS). Psoriasis, a common chronic inflammatory skin disorder, profoundly impacts the physical and psychological well-being of affected individuals.
View Article and Find Full Text PDFChlorhexidine-loaded microneedles for treatment of oral diseases.
Int J Pharm
December 2024
Department of Pharmaceutical Engineering, Azrieli College of Engineering Jerusalem, Jerusalem 9103501, Israel. Electronic address:
Chlorhexidine (CHX) is a gold standard therapeutic agent against clinical oral pathogens. However, its oral use is limited due to unpleasant taste, alteration in taste buds, staining of teeth and mucous membranes. Therefore, CHX-loaded PLGA microneedles (MNs) were fabricated for local and controlled release in the oral cavity, using a casting mold method.
View Article and Find Full Text PDFPolymeric Microneedles for Transdermal Delivery of Human Placental Tissue for the Treatment of Osteoarthritis.
Macromol Biosci
December 2024
Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, 560054, India.
Biologics targeting matrix-degrading proteases, cartilage repair, and inflammation are emerging as promising approaches for osteoarthritis (OA) treatment. Recent research highlights biologic-human placental tissue (HPT) as a potential OA therapy due to its biocompatibility, abundant protein biofactors, and ability to reduce cartilage degradation by suppressing protease expression. Microneedles (MNs) are receiving growing attention for enhancing transdermal delivery of biologics as an alternative to conventional subcutaneous injections.
View Article and Find Full Text PDFSelf-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis.
Int J Pharm
December 2024
Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:
Psoriasis is an autoimmune-driven inflammatory skin disease, clinically characterized by skin thickening, erythema, and scaling, significantly impacting patients' life quality and mental health. Clinically, oral pill or injection of methotrexate (MTX) formulation is a common route for psoriasis therapy, while both methods often cause undesired toxicity due to systemic administration, and limit patient compliance because of the frequent-dosing requirement. Here, we introduce a dissolvable microneedle (MN) patch made of polyvinyl alcohol (PVA) that incorporates self-assembled hyaluronic acid (HA) nanoparticles (NPs) conjugating MTX, which is designed for treating skin diseases, offering reduced adverse effects and improved patient adherence through its targeted and long-acting properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!