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Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications. | LitMetric

AI Article Synopsis

  • - The study examined the impact of multifocality (presence of multiple tumor sites) in 280 testicular cancer patients who underwent radical orchiectomy, aiming to find connections with clinical and pathological traits.
  • - Multifocality was found in 15.7% of patients and was linked to smaller primary tumors (average 20.0 mm) compared to those with a single tumor focus (average 30.0 mm), with a notable number of multifocal patients having tumors under 2 cm.
  • - Despite these associations, the study concluded that multifocality does not significantly affect the prognosis for advanced clinical stages of testicular cancer, as it wasn't a notable risk factor in either seminoma or non-seminoma

Article Abstract

There are limited data regarding the significance of multifocality in testicular cancer patients. This study evaluated the relationship between multifocality and clinicopathological features determined at the time of radical orchiectomy. The study involved 280 consecutive patients who underwent radical orchiectomy between 2018 and 2023. Multifocality was defined as a distinct tumor focus characterized by a group of malignant cells > 1 mm, clearly differentiated from the primary tumor mass. Uni- and multivariate logistic regression analyses were employed to investigate the association between multifocality and histopathological parameters along with potential risk factors for clinical stages II + III. Multifocality was identified in 44 (15.7%) patients. Significantly smaller primary tumors were observed in subjects with multifocality (20.0 mm vs. 30.0 mm, = 0.0001), while those exhibiting monofocality presented a markedly elevated rate of tumors exceeding 4 cm (40.3% vs. 18.2%, = 0.005). Furthermore, multifocality was associated with a significantly higher rate of primary tumors < 2 cm (52.3% vs. 29.2%, = 0.003). Univariate logistic regression analysis revealed a substantial decrease in the likelihood of multifocality occurrence in seminoma patients with tumors > 4 cm (OR = 0.38, = 0.017). Meanwhile, in multivariate logistic regression, multifocality did not emerge as a significant risk factor for clinical stages II + III in either seminoma ( = 0.381) or non-seminoma ( = 0.672) cases. Our study suggests that multifocality holds no substantial prognostic relevance for clinically advanced disease in testicular cancer patients. The findings indicate that multifocality is associated with smaller primary tumors, particularly those measuring less than 2 cm.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890071PMC
http://dx.doi.org/10.3390/life14020257DOI Listing

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