Relationship between the Expression of CHK2 and p53 in Tumor Tissue and the Course of Papillary Thyroid Cancer in Patients with Germline Mutations.

The aim of this study was to determine whether the expression of CHK2 and p53 in tumor tissue in carriers of germline mutations can serve as a prognostic marker for PTC, and whether and copy numbers correlates with the course of PTC disease. This study included 156 PTC patients previously tested for the presence of . Clinicopathological features, treatment response, disease outcome, and germline mutation status of the gene were assessed with respect to CHK2 and p53 expression, and and gene copy statuses. In patients with and without a germline mutation in and with higher CHK2 expression, the chances of an excellent treatment response and no evidence of disease were lower than in patients without or with lower CHK2 expression. deletion was associated with angioinvasion. In patients with a truncating mutation, the chance of a deletion was higher than in patients with WT alone or those with WT and with the missense I157T mutation. Higher CHK2 expression was associated with poorer treatment responses and disease outcomes. Higher CHK2 expression and positive p53 together with a deletion could be a prognostic marker of unfavorable disease outcomes in patients with germline truncating mutations in .