AI Article Synopsis
- Acetic acid is a byproduct of ethanol metabolism and has been linked to oxidative stress and changes in neuron function.
- Administration of acetic acid/acetate can increase sympathetic nervous system activity, which may affect blood pressure regulation.
- Researchers can explore the effects of ethanol and acetic acid on cardiovascular function by directly injecting these substances into brain control centers and measuring the resultant changes in nerve activity and blood pressure.
Article Abstract
Acetic acid is a bioactive short-chain fatty acid produced in large quantities from ethanol metabolism. In this review, we describe how acetic acid/acetate generates oxidative stress, alters the function of pre-sympathetic neurons, and can potentially influence cardiovascular function in both humans and rodents after ethanol consumption. Our recent findings from in vivo and in vitro studies support the notion that administration of acetic acid/acetate generates oxidative stress and increases sympathetic outflow, leading to alterations in arterial blood pressure. Real-time investigation of how ethanol and acetic acid/acetate modulate neural control of cardiovascular function can be conducted by microinjecting compounds into autonomic control centers of the brain and measuring changes in peripheral sympathetic nerve activity and blood pressure in response to these compounds.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10886048 | PMC |
| http://dx.doi.org/10.3390/antiox13020139 | DOI Listing |
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