In plants, gene regulation underlies organ development and responses to environmental changes [...].
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http://dx.doi.org/10.3390/ijms25042010 | DOI Listing |
PLoS One
January 2025
Integrative Multiomics Lab, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Background: Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate the key genes, and regulatory elements implicated in the progression and association of these diseases, thereby highlighting the linked potential therapeutic targets.
View Article and Find Full Text PDFJ Cell Biol
February 2025
Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.
Mutations that increase LRRK2 kinase activity have been linked to Parkinson's disease and Crohn's disease. LRRK2 is also activated by lysosome damage. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood.
View Article and Find Full Text PDFJ Cell Biol
February 2025
Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, USA.
Tubulin polyglutamylation is essential for maintaining cilium stability and function, and defective tubulin polyglutamylation is associated with ciliopathies. However, the regulatory mechanism underlying proper axonemal polyglutamylation remains unclear. He et al.
View Article and Find Full Text PDFMicrobiol Resour Announc
January 2025
G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Federal Research Center, Pushchino, Russia.
The genome of sp. isolated from agricultural soil polluted with the herbicide glyphosate is reported. The genome size is 5.
View Article and Find Full Text PDFAppl Environ Microbiol
January 2025
Department of Biology, Indiana University, Bloomington, Indiana, USA.
The bacterial pathogen causes disease in coral species worldwide. The mechanisms of coral colonization, coral microbiome interactions, and virulence factor production are understudied. In other model species, virulence factors like biofilm formation, toxin secretion, and protease production are controlled through a density-dependent communication system called quorum sensing (QS).
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