Tiletamine-Zolazepam, Ketamine, and Xylazine Anesthetic Protocol for High-Quality, High-Volume Spay and Neuter of Free-Roaming Cats in Seoul, Korea.

Animals (Basel)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.

Published: February 2024

This study was performed to evaluate the anesthetic protocol used in the high-quality, high-volume spay and neuter (HQHVSN) of free-roaming cats in Seoul, Korea from 2017 to 2022. The evaluation was performed on a total of 1261 free-roaming cats, with an average weight of 3.48 ± 1.04 kg. The anesthetic combination tiletamine-zolazepam, ketamine, and xylazine (ZKX) was injected intramuscularly. The actual drug doses administered were tiletamine-zolazepam 5.52 ± 1.70 mg/kg, ketamine 8.94 ± 3.60 mg/kg, and xylazine 1.11 ± 0.34 mg/kg. Additional doses were required in 275 cats out of a total of 1261 (21.8%). Following anesthesia and surgery, 1257 cats (99.7%) were returned to their original locations. Four cats (0.3%) died postoperatively. The mean duration of anesthesia (from ZKX combination to yohimbine administration) was 26 ± 22 min for males and 55 ± 36 min for females, while the time from yohimbine administration to the recovery was 31 ± 22 min for males and 20 ± 17 min for females. The use of ZKX for HQHVSN of free-roaming cats is inexpensive, provides predictable results, can be administered quickly and easily in a small volume, and is associated with a low mortality rate during the first 72 h post-surgery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10886021PMC
http://dx.doi.org/10.3390/ani14040656DOI Listing

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