AI Article Synopsis
- - Human CD4EOMES T cells consist of diverse types, including Th1-cells, Tr1-cells, and CD4CTL, each with different functions in the immune response.
- - Tr1-cells are anti-inflammatory while non-classical EOMES Th1-cells are pro-inflammatory, but both share features like producing IFN-γ and granzyme-K, which helps suppress T-cell growth.
- - A diffusion map analysis indicates a gradual differentiation of CD4 T-cells from a naïve state to cytotoxic functions, highlighting EOMES Th1-cells as potential precursors to Tr1-cells.
Article Abstract
Human CD4EOMES T cells are heterogeneous and contain Th1-cells, Tr1-cells, and CD4CTL. Tr1- cells and non-classical EOMES Th1-cells displayed, respectively, anti- and pro-inflammatory cytokine profiles, but both expressed granzyme-K, produced IFN-γ, and suppressed T-cell proliferation. Diffusion map suggested a progressive CD4T-cell differentiation from naïve to cytotoxic cells and identified EOMESTh1-cells as putative Tr1-cell precursors (pre-Tr1).
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| http://dx.doi.org/10.1002/eji.202350675 | DOI Listing |
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