Background: The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of intensive research. Recently, the green synthesis of nanoparticles and their anti-viral function have attracted a lot of attention. Previous studies have shown promising results in the use of Arabic gum for the green synthesis of nanoparticles with strong antiviral properties. In this study we aimed to investigate the antiviral effects of MnO nanoparticles (MnO-NPs) synthesized using Arabic gum, particularly against the influenza virus.
Methods: Arabic gum was used as a natural polymer to extract and synthesize MnO-NPs using a green chemistry approach. The synthesized MnO-NPs were characterized using SEM and TEM. To evaluate virus titration, cytotoxicity, and antiviral activity, TCID50, MTT, and Hemagglutination assay (HA) were performed, respectively. Molecular docking studies were also performed to investigate the potential antiviral activity of the synthesized MnO-NPs against the influenza virus. The molecular docking was carried out using AutoDock Vina software followed by an analysis with VMD software to investigate the interaction between Arabic gum and the hemagglutinin protein.
Results: Simultaneous combination treatment with the green-synthesized MnO-NPs resulted in a 3.5 log HA decrement and 69.7% cellular protection, which demonstrated the most significant difference in cellular protection compared to the virus control group (p-value < 0.01). The docking results showed that binding affinities were between - 3.3 and - 5.8 kcal/mole relating with the interaction between target with MnO and beta-D-galactopyranuronic acid, respectively.
Conclusion: The results of the study indicated that the MnO-NPs synthesized with Arabic gum had significant antiviral effects against the influenza virus, highlighting their potential as a natural and effective treatment for inhibition of respiratory infections.
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http://dx.doi.org/10.1186/s12985-024-02315-z | DOI Listing |
Food Chem
December 2024
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, Hubei 430070, PR China. Electronic address:
Improving sea buckthorn flavonoids (SF) stability and bioacccessibility is of more practical significance for evaluating the total bioacccessibility of such foods. Therefore, we prepared nanoparticles using zein and gum Arabic (GA) by anti-solvent precipitation to encapsulate SF. Nanoparticles were characterized and assessed for their effect on the stability, release, bioaccessibility, absorption, and antioxidant properties of SF in the in vitro digestion and cell line.
View Article and Find Full Text PDFJ Anim Sci Technol
November 2024
Department of Animal Production, College of Food and Agriculture Science, King Saud University, Riyadh 11451, Saudi Arabia.
The purpose of the current study was to investigate the effects of gum Arabic supplementation on short-chain fatty acids, cecal microbiota, immune-related gene expression, and small intestinal morphology in post-hatched broiler chicks. On the day of hatching, four hundred thirty-two commercial male broiler chicks were randomly allocated into six treatments with twelve cages as replicates of six chicks each for 24 days. Dietary treatments (T1 to T6) were supplemented with 0.
View Article and Find Full Text PDFMolecules
December 2024
Laboratoire de Chimie Agro-Industrielle (LCA), INRAE, Toulouse INP, Université de Toulouse, 31030 Toulouse, France.
Seed film-coatings used for seed treatment often contain microplastics which must be replaced. The objective of this study is to analyze the influence of substitutes (maltodextrin, waxy maize glucose syrup (WMGS), methylcellulose, tragacanth gum (TG), arabic gum (AG), polyvinyl alcohol (PVA), ethoxylated rapeseed oil (ERO)), and xanthan gum as a thickener on the stability of a seed film-coating via Static Multiple Light Scattering (SMLS) technology. The results demonstrate that the incorporation of each polymer results in an increase in the quantity of particles migrating from the supernatant phase, but a concomitant decrease in their sedimentation rate and in the thickness of the supernatant phase (e).
View Article and Find Full Text PDFFoods
November 2024
Faculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de São Paulo (USP), Pirassununga 13635-900, São Paulo, Brazil.
Chasteberry extract offers considerable phytotherapeutic benefits, particularly in alleviating premenstrual syndrome (PMS) symptoms. However, its hydroalcoholic nature leads to a bitter taste and a burning sensation, presenting challenges for direct consumption or incorporation into new food products. This study aimed to address these issues by encapsulating concentrated chasteberry extract using spray-drying with Arabic gum, followed by spray-chilling with vegetable fat as carriers.
View Article and Find Full Text PDFBiol Pharm Bull
December 2024
Faculty of Pharmacy, Kindai University.
In this study, we attempted to enhance the delivery of minoxidil (MXD) nanocrystals into hair follicles for efficacious hair growth treatment. We applied a bead milling method and designed an MXD nanocrystal dispersion containing methylcellulose (MC) and gum arabic (GA), termed MG-MXD@NP, with a particle size of 110 nm. In vivo studies in C57BL/6 mice showed that MG-MXD@NP improved MXD delivery to the skin tissue, hair bulges, and hair bulbs, resulting in earlier and superior hair growth compared with a commercially available MXD lotion (Riup 5%, CA-MXD).
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