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Negative valence in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium.
Biol Psychiatry
December 2024
Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands.
Objective: Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates of negative valence in OCD, we pooled fMRI data of 633 individuals with OCD and 453 healthy controls from 16 studies using different negatively-valenced tasks across the ENIGMA-OCD Working-Group.
Methods: Participant data were processed uniformly using HALFpipe, to extract voxelwise participant-level statistical images of one common first-level contrast: negative vs.
Late-Onset Musical Obsession: A Case Report of an Elderly Patient Treated in an Outpatient Psychiatry Clinic.
Cureus
October 2024
Psychiatry, Ng Teng Fong General Hospital, Singapore, SGP.
Article Synopsis
- Musical obsessions are a type of involuntary music thoughts often linked to obsessive-compulsive disorder, typically seen in young adults.
- A unique case presented an elderly patient experiencing these musical obsessions, prompting a thorough evaluation and treatment process.
- Distinguishing musical obsessions from other symptoms like auditory hallucinations and palinacousis is crucial for appropriate clinical assessment and management.
Late-Onset Obsessive-Compulsive Disorder Comprising Somatic Obsessions: Is This a Distinct and Overlooked Phenotypic Subtype?
Prim Care Companion CNS Disord
February 2024
Department of Geriatric Psychiatry, Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal.
Early-onset obsessive-compulsive disorder: Sociodemographic and clinical characterization of a large outpatient cohort.
J Psychiatr Res
April 2024
University of Milan, Department of Mental Health, Department of Biomedical and Clinical Sciences Luigi Sacco, Milan, Italy; "Aldo Ravelli" Center for Neurotechnology and Brain Therapeutic, University of Milan, Milan, Italy; Department of Psychiatry and Behavioral Sciences, Bipolar Disorders Clinic, Stanford University, CA, USA.
Introduction: Obsessive-compulsive disorder (OCD) is a prevalent and disabling condition characterized by a wide variety of phenotypic expressions. Several studies have reinforced the hypothesis of OCD heterogeneity by proposing subtypes based on predominant symptomatology, course, and comorbidities. Early-onset OCD (EO) could be considered a neurodevelopmental subtype of OCD, with evidence of distinct neurocircuits supporting disease progression.
View Article and Find Full Text PDFLink Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms.
Neuropsychiatr Dis Treat
January 2024
Department of Medical Genetics, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, 09010, Turkey.
Objective: Many researchers have considered obsessive compulsive disorder (OCD) to be a neurodegenerative disease just like Alzheimer's disease (AD). The most studied gene in neurodegenerative diseases is apolipoprotein E (ApoE) gene, and ApoE ɛ4 allele in particular. Although a small number of studies have explored the relationship between ApoE gene polymorphisms and OCD, the link between age at onset of OCD, its subtypes and ApoE gene polymorphisms has not been revealed so far.
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