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Time to Staphylococcus aureus Blood Culture Positivity as a risk marker of Infective Endocarditis: A Retrospective Cohort Study.
Clin Infect Dis
December 2024
Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden.
Background: Endocarditis occurs in approximately 10-15% of patients with Staphylococcus aureus bacteremia. Short time to positivity (TTP) in blood culture flasks has been linked to endocarditis in smaller studies. This study evaluated the association between TTP and endocarditis in S.
View Article and Find Full Text PDFThe impact of physiological state and environmental stress on bacterial load estimation methodologies for Mycobacterium tuberculosis.
Sci Rep
October 2024
Institute for Global Health, University College London, London, UK.
When processed in solid or liquid medium, tuberculosis patient samples yield different proportions of a heterogenous bacterial community over the duration of treatment. We aimed to derive a relationship between methodologies for bacterial load determination and assess the effect of the growth phase of the parent culture and its exposure to stress on the results. Mycobacterium tuberculosis H37Rv was grown with and without antibiotic (isoniazid or rifampicin) and sampled on day 0, 3, 11 and 21 of growth in broth culture.
View Article and Find Full Text PDFComparison of bloodstream infections due to Corynebacterium striatum, MRSA, and MRSE.
BMC Infect Dis
September 2024
Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing, 100730, China.
Article Synopsis
- Corynebacterium striatum is increasingly recognized as an opportunistic pathogen causing bloodstream infections (BSIs), necessitating a study on its clinical features and outcomes.
- The study involved analyzing hospitalized patients with C. striatum-positive blood cultures over several years, comparing cases identified as actual infections (C. striatum-BSI) with those deemed as contamination, as well as comparing them to MRSA and MRSE infections.
- Results showed that C. striatum-BSI had longer time to positivity in blood cultures and higher 28-day mortality compared to MRSA and MRSE, highlighting the need for early appropriate antibiotic treatment when C. striatum-BSI is suspected.
Time-to-Positivity for Candida in Bloodstream Infections: Prognostic Implications for Mortality.
Cureus
August 2024
Department of Microbiology, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Background -associated catheter-related bloodstream infections (CRBSIs) present a significant challenge in clinical settings, particularly among patients with central venous catheters (CVCs). Time-to-positivity (TTP) of blood cultures, an indicator of fungal load, may provide insights into infection prognosis and severity. This study evaluates the role of TTP in -associated bloodstream infections and its impact on patient outcomes.
View Article and Find Full Text PDFTime to Positivity of Blood Culture as a Predictor of Causative Pathogens and Survival in Neonatal Sepsis: A Retrospective Cohort Study from Indonesia.
Oman Med J
January 2024
Department of Clinical Microbiology, Dr. Soetomo General Hospital, Surabaya, Indonesia.
Objectives: In the blood culture procedure for neonatal sepsis, time to positivity (TTP) reflects the pathogenic bacterial load and the time required for empirical antibiotic regimen administration prior to definitive treatment. This study aims to identify the differences in TTP among causative pathogens and its predictive value for the overall survival of neonates with sepsis at a tertiary healthcare center in Indonesia.
Methods: A retrospective cohort study was conducted from January 2020 to August 2022 at Dr.
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