Meirols A-C: Bioactive Catecholic Compounds from the Marine-Derived Fungus sp. 1210CH-42.

Three new catecholic compounds, named meirols A-C (-), and one known analog, argovin (), were isolated from the marine-derived fungus sp. 1210CH-42. Their structures were determined by extensive analysis of 1D, 2D NMR, and HR-ESIMS spectroscopic data. Their absolute configurations were elucidated based on ECD calculations. All the compounds exhibited strong antioxidant capabilities with EC values ranging from 6.01 to 7.47 μM (ascorbic acid, EC = 7.81 μM), as demonstrated by DPPH radical scavenging activity assays. In the α-glucosidase inhibition assay, and showed potent in vitro inhibitory activity with IC values of 184.50 and 199.70 μM, respectively (acarbose, IC = 301.93 μM). Although none of the isolated compounds exhibited cytotoxicity against one normal and six solid cancer cell lines, exhibited moderate cytotoxicity against the NALM6 and RPMI-8402 blood cancer cell lines with GI values of 9.48 and 21.00 μM, respectively. Compound also demonstrated weak cytotoxicity against the NALM6 blood cancer cell line with a GI value of 29.40 μM.